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(Rac)-AMXT-1501 4HCl

Name: (Rac)-AMXT-1501 4HCl
Brand: TargetMol
SKU: T10313
Price: 183 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10313Cas No. 2771343-93-0

(Rac)-AMXT-1501 4HCl is a polyamine transport inhibitor that inhibits polyamine transport and acts synergistically with cisplatin in HNSCC. (Rac)-AMXT-1501 4HCl has potential antimicrobial activity and inhibits neuroblastoma cell proliferation and pneumococcal pod biosynthesis by targeting ornithine decarboxylase and polyamine transport.

(Rac)-AMXT-1501 4HCl

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Purity: 98.31%

Catalog No. T10313Cas No. 2771343-93-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$183	In Stock	In Stock
2 mg	$269	In Stock	In Stock
5 mg	$456	In Stock	In Stock
10 mg	$697	In Stock	In Stock
25 mg	$1,530	In Stock	In Stock
50 mg	$2,360	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.31%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	(Rac)-AMXT-1501 4HCl is a polyamine transport inhibitor that inhibits polyamine transport and acts synergistically with cisplatin in HNSCC. (Rac)-AMXT-1501 4HCl has potential antimicrobial activity and inhibits neuroblastoma cell proliferation and pneumococcal pod biosynthesis by targeting ornithine decarboxylase and polyamine transport.
In vitro	In BE(2)-C, SMS-KCNR, and SH-SY5Y cells, AMXT-1501 tetrahydrochloride (0.39 µM, 1 µM, 3.1 µM, 10 µM, 31 µM, 50 µM; 48 hours) exhibited cytotoxicity against this panel of NB cell lines[2].
In vivo	In C57BL/6 (WT) and experimental autoimmune encephalomyelitis (EAE) model-bearing ODC knockout strain (ODC cKO) mice, AMXT-1501 tetrahydrochloride (3 mg/kg; subcutaneous injection; once daily; 28 days) initially displayed a delayed disease onset but eventually proceeded with pathological development and reached the endpoint[3].

Chemical Properties

Molecular Weight	714.77
Formula	C₃₂H₇₂Cl₄N₆O₂
Cas No.	2771343-93-0
Smiles	O=C(CCCCCCCCCCCCCCC)NCCCCC(C(NCCCNCCCCNCCCN)=O)N.Cl.Cl.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 72.5 mg/mL (101.43 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.3991 mL	6.9953 mL	13.9905 mL	69.9526 mL
5 mM	0.2798 mL	1.3991 mL	2.7981 mL	13.9905 mL
10 mM	0.1399 mL	0.6995 mL	1.3991 mL	6.9953 mL
20 mM	0.0700 mL	0.3498 mL	0.6995 mL	3.4976 mL
50 mM	0.0280 mL	0.1399 mL	0.2798 mL	1.3991 mL
100 mM	0.0140 mL	0.0700 mL	0.1399 mL	0.6995 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc