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Epinastine hydrochloride

Name: Epinastine hydrochloride
Brand: TargetMol
SKU: T6488
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6488Cas No. 108929-04-0

Alias WAL-801CL HCl, Epinastine HCl, Elestat, Alesion

Epinastine hydrochloride (WAL-801CL HCl) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.

Epinastine hydrochloride

🥰Excellent

Purity: 99.62%

Catalog No. T6488Alias WAL-801CL HCl, Epinastine HCl, Elestat, AlesionCas No. 108929-04-0

Epinastine hydrochloride (WAL-801CL HCl) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.

Pack Size	Price	Availability
10 mg	$33	In Stock
25 mg	$50	In Stock
50 mg	$65	In Stock
100 mg	$97	In Stock
200 mg	$183	In Stock
500 mg	$339	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Purity:99.62%

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COA LCMS

Product Introduction

Bioactivity

Description	Epinastine hydrochloride (WAL-801CL HCl) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.
In vitro	Epinastine shows a high affinity to H1-receptors in receptor binding studies in the guinea pig ileum. [1] Epinastine is able to displace specific [3H]NC-5Z binding at low concentrations in the locust nervous tissue. Epinastine binds to the honey bees neuronal octopamine receptor with Ki of 1.1 nM. Epinastine antagonises octopamine-induced cAMP formation in the insect brain. [2] Epinastine causes an inhibition of histamine release from rat peritoneal mast cells induced by both antigen-antibody reaction and compound 48/80. Epinastine is similarly effective in inhibiting compound 48/80-induced histamine release not only from isolated rat peritoneal mast cells but also from rat mesenterial pieces. Epinastine is effective in inhibiting not only Ca2+ uptake into lung mast cells in actively sensitized guinea pigs but also Ca2+ release from the intracellular Ca store of rat peritoneal mast cells exposed to both compound 48/80 and substance P. [3] Epinastine shows a dose- and time-dependent suppressive effect on IL-8, one of the chemokines for eosinophils, released from eosinophils isolated from atopic diseases. [4]
In vivo	Epinastine inhibits histamine-induced reactions in the skin or the lung of rats, dogs and guinea pigs. [1]
Synonyms	WAL-801CL HCl, Epinastine HCl, Elestat, Alesion

Chemical Properties

Molecular Weight	285.77
Formula	C₁₆H₁₅N₃·HCl
Cas No.	108929-04-0
Smiles	Cl[H].NC1=NCC2N1C1=CC=CC=C1CC1=CC=CC=C21
Relative Density.	1.32g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (174.97 mM), Sonication is recommended.

H2O: 52 mg/mL (181.96 mM), Sonication is recommended.

Ethanol: 53 mg/mL (185.46 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.4993 mL	17.4966 mL	34.9932 mL	174.9659 mL
5 mM	0.6999 mL	3.4993 mL	6.9986 mL	34.9932 mL
10 mM	0.3499 mL	1.7497 mL	3.4993 mL	17.4966 mL
20 mM	0.1750 mL	0.8748 mL	1.7497 mL	8.7483 mL
50 mM	0.0700 mL	0.3499 mL	0.6999 mL	3.4993 mL
100 mM	0.0350 mL	0.1750 mL	0.3499 mL	1.7497 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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