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Estetrol

Name: Estetrol
Brand: TargetMol
SKU: T15248
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15248Cas No. 15183-37-6

Alias Donesta

Estetrol(Donesta) is an orally available, selective modulator of the estrogen receptor, a naturally occurring estrogen synthesized by the human fetal liver during pregnancy.Estetrol has effects on the endometrium or central nervous system, but is antagonistic to the breast.Estetrol may help to reduce thrombosis at low concentrations. Estetrol may be used to relieve menopausal symptoms.

Estetrol

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Purity: 99.93%

Catalog No. T15248Alias DonestaCas No. 15183-37-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	-	In Stock
5 mg	$81	-	In Stock
10 mg	$139	-	In Stock
25 mg	$297	-	In Stock
50 mg	$513	-	In Stock
100 mg	$859	-	In Stock
200 mg	$1,160	-	In Stock
1 mL x 10 mM (in DMSO)	$89	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Estetrol AI Summary

Estetrol exhibits bioactivity related to binding to estrogen receptors (ERalpha and ERbeta), showing a Ki value of 19.0 nM for ERalpha and 4.9 nM for ERbeta in binding assays using [3H]E2 as the labeled ligand. Additionally, Estetrol demonstrates antiviral properties, inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 µM concentration with an inhibition rate of 0.57% after 48 hours, and shows an inhibitory effect of 3.432% on the SARS-CoV-2 3CL-Pro protease at 20 µM concentration in a FRET-based assay. Furthermore, the compound shows inhibitory activity in enzymatic assays of human HDAC6, with inhibition rates of 5.04% and 7.99% using commercial and custom peptide substrates, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Estetrol(Donesta) is an orally available, selective modulator of the estrogen receptor, a naturally occurring estrogen synthesized by the human fetal liver during pregnancy.Estetrol has effects on the endometrium or central nervous system, but is antagonistic to the breast.Estetrol may help to reduce thrombosis at low concentrations. Estetrol may be used to relieve menopausal symptoms.
Synonyms	Donesta

Chemical Properties

Molecular Weight	304.38
Formula	C₁₈H₂₄O₄
Cas No.	15183-37-6
Smiles	C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=CC4)(CC1)[H])[H])([C@@H](O)[C@@H](O)[C@@H]2O)[H]
Relative Density.	1.343 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (295.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2854 mL	16.4268 mL	32.8537 mL	164.2683 mL
5 mM	0.6571 mL	3.2854 mL	6.5707 mL	32.8537 mL
10 mM	0.3285 mL	1.6427 mL	3.2854 mL	16.4268 mL
20 mM	0.1643 mL	0.8213 mL	1.6427 mL	8.2134 mL
50 mM	0.0657 mL	0.3285 mL	0.6571 mL	3.2854 mL
100 mM	0.0329 mL	0.1643 mL	0.3285 mL	1.6427 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc