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STUB1 Protein, Human, Recombinant (His)
(Synonyms: STUB1, E3 ubiquitin-protein ligase CHIP, CHIP, Antigen NY-CO-7) Copy Product InfoSynonyms: STUB1, E3 ubiquitin-protein ligase CHIP, CHIP, Antigen NY-CO-7
Catalog No. TMPC-00134 Copy Product Info
STUB1 Protein, Human, Recombinant (His) is expressed in E. coli. The accession number is Q9UNE7.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 20 μg | $513 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:>90% as determined by SDS-PAGE.
Appearance:Solution
Color:Transparent
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. |
| Description | STUB1 Protein, Human, Recombinant (His) is expressed in E. coli. The accession number is Q9UNE7. |
| Species | Human |
| Expression System | E. coli |
| Tag | N-His |
| Accession Number | Q9UNE7 |
| Construction | Recombinant full length human STUB1 (CHIP) was expressed in E. coli cells using an N-terminal His tag. |
| Protein Purity | >90% as determined by SDS-PAGE.  |
| Formulation | Supplied as sterile 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products. |
| Synonyms | STUB1, E3 ubiquitin-protein ligase CHIP, CHIP, Antigen NY-CO-7 |
| Research Background | CHIP, the protein encoded by STUB1, is a central component of cellular protein homeostasis and interacts with several key proteins involved in the pathogenesis of manifold neurodegenerative diseases. Missense and truncating mutations in STUB1 lead to SCAR16. CHIP/STUB1 ubiquitin ligase is a negative co-chaperone for HSP90/HSC70, and its expression is reduced or lost in several cancers, including breast cancer. Pathogenic variants in STUB1 were initially described in autosomal recessive spinocerebellar ataxia type 16 and dominant cerebellar ataxia with cerebellar cognitive dysfunction (SCA48). Data indicated that STUB1 deficiency leads both to the intracellular accumulation of protein aggregates and to an increase in the secretion of small extracellular vesicles (sEVs), including exosomes. Secreted sEVs are enriched in ubiquitinated and/or undegraded proteins and protein oligomers. |
| Molecular Weight | ~37 kDa |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: STUB1 Protein, Human, Recombinant (His) chemical structure | STUB1 Protein, Human, Recombinant (His) molecular weight
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