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S2101

Name: S2101
Brand: TargetMol
SKU: T13052
Rating: 4.5 (1 reviews)

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Catalog No. T13052Cas No. 1239262-36-2

Alias S 2101

S2101 is a specific LSD1 histone demethylase inhibitor with an IC50 of 0.99 μM and a Ki of 0.61 μM, suitable for research into cancer and viral infections.

S2101

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Catalog No. T13052Alias S 2101Cas No. 1239262-36-2

S2101 is a specific LSD1 histone demethylase inhibitor with an IC50 of 0.99 μM and a Ki of 0.61 μM, suitable for research into cancer and viral infections.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$149	7-10 days	7-10 days
2 mg	Preferential	7-10 days	7-10 days
5 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	S2101 is a specific LSD1 histone demethylase inhibitor with an IC50 of 0.99 μM and a Ki of 0.61 μM, suitable for research into cancer and viral infections.
Targets&IC50	LSD1:0.61 μM (ki), LSD1:0.99 μM
In vitro	S2101 is an inhibitor of lysine-specific demethylase 1 (LSD1)(IC50 of 0.99 μM, Ki of 0.61 μM, and Kinact/Ki of 4560 M/s). S2101 also displays much lower inhibition activity toward MAO-B with a Ki of 17 μM and Kinact/Ki of 18 M/s and MAOin-A (Ki=110 μM, Kinact/Ki=60 M/s). The treatment of HEK293T cells with S2101 Results in a dose-dependent increase in the level of H3K4me2, which must have accumulated by the inactivation of LSD1. During the course of S2101 treatment, the amounts of histone H3 and LSD1 in the nuclear extracts remain essentially unaffected. Because the treatment with 1 μM S2101 generates a level of H3K4me2 similar to that elicited by 50 μM 2-PCPA, In human cells, S2101 is assumed to have approximately 50-fold stronger LSD1 inhibition activity than 2-PCPA.[1]
Synonyms	S 2101

Chemical Properties

Molecular Weight	311.75
Formula	C₁₆H₁₆ClF₂NO
Cas No.	1239262-36-2
Smiles	O(CC1=CC=CC=C1)C2=C(C=C(F)C=C2F)[C@H]3[C@H](N)C3.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (256.62 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2077 mL	16.0385 mL	32.0770 mL	160.3849 mL
5 mM	0.6415 mL	3.2077 mL	6.4154 mL	32.0770 mL
10 mM	0.3208 mL	1.6038 mL	3.2077 mL	16.0385 mL
20 mM	0.1604 mL	0.8019 mL	1.6038 mL	8.0192 mL
50 mM	0.0642 mL	0.3208 mL	0.6415 mL	3.2077 mL
100 mM	0.0321 mL	0.1604 mL	0.3208 mL	1.6038 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc