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ELOVL6-IN-1

Name: ELOVL6-IN-1
Brand: TargetMol
SKU: T9214
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9214Cas No. 1185736-98-4

ELOVL6-IN-1 is a potent, orally active, and selective ELOVL6 inhibitor that dose-dependently inhibits mouse ELOVL6 activities with an IC50 value of 0.350 μM. It inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA[1].

ELOVL6-IN-1

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Purity: 99.54%

Catalog No. T9214Cas No. 1185736-98-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$202	In Stock	In Stock
25 mg	$331	In Stock	In Stock
50 mg	$453	In Stock	In Stock
100 mg	$622	In Stock	In Stock
200 mg	$833	-	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.54%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	ELOVL6-IN-1 is a potent, orally active, and selective ELOVL6 inhibitor that dose-dependently inhibits mouse ELOVL6 activities with an IC50 value of 0.350 μM. It inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA[1].
Targets&IC50	ELOVL6:0.35 μM, ELOVL6:994 nM(ki)
In vitro	ELOVL6-IN-1 has sufficiently lipophilic. It has the potential to penetrate the intracellular space in a passive diffusion manner potentially[1].
In vivo	ELOVL6-IN-1 (10 mg/kg; p.o.; 0~2 hours) shows significant plasma and liver exposure[1]. At doses of 10 and 30 mg/kg (p.o.; 0~2 hours), it reduces the elongation index of liver lipids[1]. Additionally, a dose of 100 mg/kg (p.o.; 2 days) decreases the elongation index of total liver fatty acids[1].

Chemical Properties

Molecular Weight	495.49
Formula	C₂₇H₂₄F₃N₃O₃
Cas No.	1185736-98-4
Smiles	Cc1[nH]n(-c2ccccc2)c(=O)c1C1(C(=O)N(C2=C1C(=O)C(C)(C)CC2)c1ccccc1)C(F)(F)F
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (90.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0182 mL	10.0910 mL	20.1820 mL	100.9102 mL
5 mM	0.4036 mL	2.0182 mL	4.0364 mL	20.1820 mL
10 mM	0.2018 mL	1.0091 mL	2.0182 mL	10.0910 mL
20 mM	0.1009 mL	0.5046 mL	1.0091 mL	5.0455 mL
50 mM	0.0404 mL	0.2018 mL	0.4036 mL	2.0182 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc