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ST2/IL-1 RL1 Protein, Human, Recombinant (hFc)

Catalog No. TMPY-00849
Synonyms: ST2V, FIT-1, DER4, interleukin 1 receptor-like 1, T1, IL‑1 R4, IL33R, ST2, ST2L, IL1RL1

ST2/IL-1 RL1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.72 kDa and the accession number is Q01638-2.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
ST2/IL-1 RL1 Protein, Human, Recombinant (hFc)
Pack Size Availability Price/USD Quantity
100 μg In stock $ 255.00
200 μg 5 days $ 451.00
500 μg 5 days $ 956.00
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Biological Description
Technical Params
Product Properties
References and Literature
Biological Information Measured by its binding ability in a functional ELISA. Immobilized human IL-33 at 10 μg/ml (100 μl/well) can bind human IL1RL1 / Fc Chimera with a linear range of 0.31-5 ng/ml.

Description ST2/IL-1 RL1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.72 kDa and the accession number is Q01638-2.
Species Human
Expression System HEK293 Cells
Tag C-hFc
Accession Number Q01638-2
Synonyms ST2V, FIT-1, DER4, interleukin 1 receptor-like 1, T1, IL‑1 R4, IL33R, ST2, ST2L, IL1RL1
Construction The Human IL1RL1 isoform 2 (NP_003847.2) (Met 1-Phe 328) was fused with the Fc region of Human IgG1 at the C-terminus.
Protein Purity ≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.

Molecular Weight 61.72 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage proinflammatory function. IL33 is a specific ligand of ST2L and induces the production of Th2 cytokines.

References and Literature

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Keywords

ST2/IL-1 RL1 Protein, Human, Recombinant (hFc) ST-2 ST2V FIT-1 DER4 T 1 interleukin 1 receptor-like 1 FIT1 DER-4 T-1 DER 4 T1 IL‑1 R4 IL33R ST2 ST2L FIT 1 IL1RL1 ST 2 recombinant recombinant-proteins proteins protein

 

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