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HeE1-2Tyr

Name: HeE1-2Tyr
Brand: TargetMol
SKU: T9618
Price: 66 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9618Cas No. 2245195-67-7

HeE1-2Tyr, a pyridobenzothiazole compound, is a potent inhibitor of flavivirus RNA-dependent RNA polymerases (RdRp). It significantly inhibits the RdRp activity of West Nile, Dengue, and SARS-CoV-2 in vitro, with an IC50 of 27.6 µM.

HeE1-2Tyr

🥰Excellent

Purity: 99.51%

Catalog No. T9618Cas No. 2245195-67-7

Pack Size	Price	Availability
1 mg	$66	In Stock
5 mg	$158	In Stock
10 mg	$263	In Stock
25 mg	$463	In Stock
50 mg	$653	In Stock
100 mg	$928	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock

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Batch Information

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Purity:99.51%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	HeE1-2Tyr, a pyridobenzothiazole compound, is a potent inhibitor of flavivirus RNA-dependent RNA polymerases (RdRp). It significantly inhibits the RdRp activity of West Nile, Dengue, and SARS-CoV-2 in vitro, with an IC50 of 27.6 µM.
Targets&IC50	RdRps (SARS CoV-2):27.6 µM

Chemical Properties

Molecular Weight	582.67
Formula	C₃₃H₃₀N₂O₆S
Cas No.	2245195-67-7
Smiles	OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1cc(-c2ccccc2)c(=O)n2c3cc(OC4CCCCC4)ccc3sc12
Relative Density.	1.45 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (171.62 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7162 mL	8.5812 mL	17.1624 mL	85.8119 mL
5 mM	0.3432 mL	1.7162 mL	3.4325 mL	17.1624 mL
10 mM	0.1716 mL	0.8581 mL	1.7162 mL	8.5812 mL
20 mM	0.0858 mL	0.4291 mL	0.8581 mL	4.2906 mL
50 mM	0.0343 mL	0.1716 mL	0.3432 mL	1.7162 mL
100 mM	0.0172 mL	0.0858 mL	0.1716 mL	0.8581 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc