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MK-8719

Name: MK-8719
Brand: TargetMol
SKU: T12070
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12070Cas No. 1382799-40-7

MK-8719 is a highly potent and selective inhibitor of O-GlcNAcase (OGA) [hOGA], with a Ki value of 7.9 nM.

MK-8719

🥰Excellent

Purity: 99.67%

Catalog No. T12070Cas No. 1382799-40-7

MK-8719 is a highly potent and selective inhibitor of O-GlcNAcase (OGA) [hOGA], with a Ki value of 7.9 nM.

Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$197	In Stock
10 mg	$328	In Stock
25 mg	$558	In Stock
50 mg	$788	In Stock
100 mg	$1,120	In Stock
1 mL x 10 mM (in DMSO)	$292	In Stock

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Batch Information

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Purity:99.67%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	MK-8719 is a highly potent and selective inhibitor of O-GlcNAcase (OGA) [hOGA], with a Ki value of 7.9 nM.
Targets&IC50	O-GlcNAcase (OGA):ki:7.9 nM
In vivo	MK-8719 has excellent intrinsic potency and selectivity, high CNS exposure, improved Papp, favorable metabolic stability, good pharmacokinetics, and robust pharmacodynamic response[1].

Chemical Properties

Molecular Weight	268.28
Formula	C₉H₁₄F₂N₂O₃S
Cas No.	1382799-40-7
Smiles	[H][C@]12O[C@H](C(F)F)[C@@H](O)[C@H](O)[C@@]1([H])N=C(NCC)S2
Relative Density.	1.78 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (186.37 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.45 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7274 mL	18.6372 mL	37.2745 mL	186.3724 mL
5 mM	0.7455 mL	3.7274 mL	7.4549 mL	37.2745 mL
10 mM	0.3727 mL	1.8637 mL	3.7274 mL	18.6372 mL
20 mM	0.1864 mL	0.9319 mL	1.8637 mL	9.3186 mL
50 mM	0.0745 mL	0.3727 mL	0.7455 mL	3.7274 mL
100 mM	0.0373 mL	0.1864 mL	0.3727 mL	1.8637 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc