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IL12RB2 Protein, Mouse, Recombinant (hFc)
(Synonyms: interleukin-12 receptor β-2 chain, interleukin-12 receptor subunit β-2, interleukin-12 receptor subunit beta-2, interleukin-12 receptor beta-2 chain, IL-12R-β-2, IL-12R-beta-2, IL-12RB2, IL12RB2, IL-12R subunit β-2, IL-12R subunit beta-2, IL-12 receptor β 2, IL-12 receptor subunit β-2, IL-12 receptor subunit beta-2, IL-12 receptor beta 2) Copy Product InfoSynonyms: interleukin-12 receptor β-2 chain, interleukin-12 receptor subunit β-2, interleukin-12 receptor subunit beta-2, interleukin-12 receptor beta-2 chain, IL-12R-β-2, IL-12R-beta-2, IL-12RB2, IL12RB2, IL-12R subunit β-2, IL-12R subunit beta-2, IL-12 receptor β 2, IL-12 receptor subunit β-2, IL-12 receptor subunit beta-2, IL-12 receptor beta 2
Catalog No. TMPJ-00398 Copy Product Info
The IL12 receptor complex, formed by IL12RB1 and IL12RB2, mediates the type I immune responses of various types of lymphocytes. Its ligand, IL12, is a heterodimeric cytokine composed of IL-12p35 and IL-12p40 subunits that are linked via disulfide bonds. Ligation of IL-12 to its receptor involves the binding of IL-12p35 to IL12RB1 and IL-12p40 to IL12RB2. This will result in the activation of tyrosine kinase 2 (TYK2), which is associated with the IL12RB1 chain and Janus kinase 2 (JAK2), which is associated with the IL12RB2 chain. Activated TYK2 and JAK2 direct the phosphorylation of STAT4. IL12RB1 is present on all lymphocytes, while the expression of IL12RB2 is tightly regulated. It has shown that the expression of IL12RB2 is limited to Th2 cells. IL12RB2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $72 | 7-10 days | 7-10 days | |
| 10 μg | $116 | 7-10 days | 7-10 days | |
| 20 μg | $176 | 7-10 days | 7-10 days | |
| 50 μg | $310 | 7-10 days | 7-10 days | |
| 100 μg | $532 | 7-10 days | 7-10 days | |
| 200 μg | $919 | 7-10 days | 7-10 days | |
| 500 μg | $1,900 | 7-10 days | 7-10 days | |
| 1 mg | $2,730 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | The IL12 receptor complex, formed by IL12RB1 and IL12RB2, mediates the type I immune responses of various types of lymphocytes. Its ligand, IL12, is a heterodimeric cytokine composed of IL-12p35 and IL-12p40 subunits that are linked via disulfide bonds. Ligation of IL-12 to its receptor involves the binding of IL-12p35 to IL12RB1 and IL-12p40 to IL12RB2. This will result in the activation of tyrosine kinase 2 (TYK2), which is associated with the IL12RB1 chain and Janus kinase 2 (JAK2), which is associated with the IL12RB2 chain. Activated TYK2 and JAK2 direct the phosphorylation of STAT4. IL12RB1 is present on all lymphocytes, while the expression of IL12RB2 is tightly regulated. It has shown that the expression of IL12RB2 is limited to Th2 cells. IL12RB2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules. |
| Species | Mouse |
| Expression System | HEK293 Cells |
| Tag | C-hFc |
| Accession Number | P97378 |
| Amino Acid | Met1-Asn637 |
| Construction | Met1-Asn637 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | interleukin-12 receptor β-2 chain, interleukin-12 receptor subunit β-2, interleukin-12 receptor subunit beta-2, interleukin-12 receptor beta-2 chain, IL-12R-β-2, IL-12R-beta-2, IL-12RB2, IL12RB2, IL-12R subunit β-2, IL-12R subunit beta-2, IL-12 receptor β 2, IL-12 receptor subunit β-2, IL-12 receptor subunit beta-2, IL-12 receptor beta 2 |
| Research Background |
| Molecular Weight | 125-160 KDa (reducing condition) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Related Tags: IL12RB2 Protein, Mouse, Recombinant (hFc) chemical structure | IL12RB2 Protein, Mouse, Recombinant (hFc) molecular weight
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