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IL-12RB2 Protein, Mouse, Recombinant (hFc)

Catalog No. TMPJ-00398
Synonyms: interleukin-12 receptor β-2 chain, IL-12RB2, interleukin-12 receptor subunit beta-2, IL-12R subunit β-2, IL-12R subunit beta-2, IL-12R-beta-2, interleukin-12 receptor beta-2 chain, IL-12 receptor beta 2, interleukin-12 receptor subunit β-2, IL-12 receptor β 2, IL-12 receptor subunit β-2, IL-12R-β-2, IL-12 receptor subunit beta-2, IL12RB2

The IL12 receptor complex, formed by IL12RB1 and IL12RB2, mediates the type I immune responses of various types of lymphocytes. Its ligand, IL12, is a heterodimeric cytokine composed of IL-12p35 and IL-12p40 subunits that are linked via disulfide bonds. Ligation of IL-12 to its receptor involves the binding of IL-12p35 to IL12RB1 and IL-12p40 to IL12RB2. This will result in the activation of tyrosine kinase 2 (TYK2), which is associated with the IL12RB1 chain and Janus kinase 2 (JAK2), which is associated with the IL12RB2 chain. Activated TYK2 and JAK2 direct the phosphorylation of STAT4. IL12RB1 is present on all lymphocytes, while the expression of IL12RB2 is tightly regulated. It has shown that the expression of IL12RB2 is limited to Th2 cells. IL12RB2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules.

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IL-12RB2 Protein, Mouse, Recombinant (hFc)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 116.00
50 μg 5 days $ 310.00
500 μg 5 days $ 1,900.00
1 mg 5 days $ 2,730.00
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Biological Description
Technical Params
Product Properties
Description The IL12 receptor complex, formed by IL12RB1 and IL12RB2, mediates the type I immune responses of various types of lymphocytes. Its ligand, IL12, is a heterodimeric cytokine composed of IL-12p35 and IL-12p40 subunits that are linked via disulfide bonds. Ligation of IL-12 to its receptor involves the binding of IL-12p35 to IL12RB1 and IL-12p40 to IL12RB2. This will result in the activation of tyrosine kinase 2 (TYK2), which is associated with the IL12RB1 chain and Janus kinase 2 (JAK2), which is associated with the IL12RB2 chain. Activated TYK2 and JAK2 direct the phosphorylation of STAT4. IL12RB1 is present on all lymphocytes, while the expression of IL12RB2 is tightly regulated. It has shown that the expression of IL12RB2 is limited to Th2 cells. IL12RB2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules.
Species Mouse
Expression System Human Cells
Tag C-Fc
Accession Number P97378
Synonyms interleukin-12 receptor β-2 chain, IL-12RB2, interleukin-12 receptor subunit beta-2, IL-12R subunit β-2, IL-12R subunit beta-2, IL-12R-beta-2, interleukin-12 receptor beta-2 chain, IL-12 receptor beta 2, interleukin-12 receptor subunit β-2, IL-12 receptor β 2, IL-12 receptor subunit β-2, IL-12R-β-2, IL-12 receptor subunit beta-2, IL12RB2
Amino Acid Met1-Asn637
Construction Recombinant Mouse Interleukin-12 Receptor Subunit Beta-2 is produced by our Mammalian expression system and the target gene encoding Met1-Asn637 is expressed with a human IgG1 Fc tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 125-160 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background The IL12 receptor complex, formed by IL12RB1 and IL12RB2, mediates the type I immune responses of various types of lymphocytes. Its ligand, IL12, is a heterodimeric cytokine composed of IL-12p35 and IL-12p40 subunits that are linked via disulfide bonds. Ligation of IL-12 to its receptor involves the binding of IL-12p35 to IL12RB1 and IL-12p40 to IL12RB2. This will result in the activation of tyrosine kinase 2 (TYK2), which is associated with the IL12RB1 chain and Janus kinase 2 (JAK2), which is associated with the IL12RB2 chain. Activated TYK2 and JAK2 direct the phosphorylation of STAT4. IL12RB1 is present on all lymphocytes, while the expression of IL12RB2 is tightly regulated. It has shown that the expression of IL12RB2 is limited to Th2 cells. IL12RB2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules.

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Keywords

IL-12RB2 Protein, Mouse, Recombinant (hFc) IL-12R subunit b-2 interleukin-12 receptor b-2 chain interleukin-12 receptor β-2 chain IL-12RB2 IL-12 receptor subunit b-2 interleukin-12 receptor subunit beta-2 IL-12R subunit β-2 IL-12R subunit beta-2 IL-12R-beta-2 interleukin-12 receptor beta-2 chain IL-12 receptor beta 2 interleukin-12 receptor subunit β-2 IL-12R-b-2 IL-12 receptor β 2 IL-12 receptor subunit β-2 IL-12R-β-2 IL-12 receptor b 2 IL-12 receptor subunit beta-2 IL12RB2 interleukin-12 receptor subunit b-2 recombinant recombinant-proteins proteins protein

 

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