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Anti-BIRC5 Antibody (3G480)
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Catalog No. TMAH-00115
Alias IAP4, EPR-1, BIRC5, baculoviral IAP repeat containing 5, API4
Anti-BIRC5 Antibody (3G480) is an antibody targeting BIRC5. Anti-BIRC5 Antibody (3G480) can be used in ELISA, IHC.
Anti-BIRC5 Antibody (3G480)
Anti-BIRC5 Antibody (3G480)
😃Good
Catalog No. TMAH-00115Alias IAP4, EPR-1, BIRC5, baculoviral IAP repeat containing 5, API4
Anti-BIRC5 Antibody (3G480) is an antibody targeting BIRC5. Anti-BIRC5 Antibody (3G480) can be used in ELISA, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $207 | 7-10 days | |
| 100 μL | $349 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-BIRC5 Antibody (3G480) is an antibody targeting BIRC5. Anti-BIRC5 Antibody (3G480) can be used in ELISA, IHC. |
| Alias | IAP4, EPR-1, BIRC5, baculoviral IAP repeat containing 5, API4 |
| Ig Type | Rabbit IgG |
| Clone | 3G480 |
| Reactivity | Human |
| Verified Activity | IHC image of TMAH-00115 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| Application | ELISA, IHC |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Essential for the maintenance of mitochondrial integrity and function. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Survivin |
| Antigen Species | Human |
| Gene ID | 332 |
| Uniprot ID | |
| Biology Area | Neuroscience, Cancer, Cell biology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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