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Anti-ARNTL2 Polyclonal Antibody is a Rabbit antibody targeting ARNTL2. Anti-ARNTL2 Polyclonal Antibody can be used in WB.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $221 | 7-10 days | |
100 μL | $373 | 7-10 days | |
200 μL | $529 | 7-10 days |
Description | Anti-ARNTL2 Polyclonal Antibody is a Rabbit antibody targeting ARNTL2. Anti-ARNTL2 Polyclonal Antibody can be used in WB. |
Synonyms | wu:fj90c09, Transcription factor BMAL2, Transcription factor BMAL 2, PASD9, PASD 9, MOP9, MOP 9, MGC158186, MGC149672, MGC149671, MGC124257, Member of PAS protein 9, CYCLE-like factor, CLIF, Brain and muscle ARNT like 2, BMAL2, BMAL 2, BMA L2, bHLHe6, Basic-helix-loop-helix-PAS protein MOP9, Aryl hydrocarbon receptor nuclear translocator like 2, ARNTL2, ARNTL 2, ARNT L2 |
Ig Type | IgG |
Reactivity | Mouse,Rat (predicted:Human) |
Verified Activity | Sample: Lane 1: Testis (Mouse) Lysate at 40 μg Lane 2: Testis (Rat) Lysate at 40 μg Primary: Anti-ARNTL2 (TMAB-00147) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 71/63 kDa Observed band size: 65 kDa |
Application | |
Recommended Dose | WB: 1:500-2000 |
Antibody Type | Polyclonal |
Host Species | Rabbit |
Subcellular Localization | Nuclear |
Tissue Specificity | Expressed in fetal brain. Highly expressed in brain and placenta. Lower levels in heart, liver, thymus, kidney and lung. Located to endothelial cells and neuronal cells of the suprachiasmatic nucleus (SCN). Also detected in endothelial cells of the heart, |
Construction | Polyclonal Antibody |
Purification | Protein A purified |
Appearance | Liquid |
Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Concentration | 1 mg/mL |
Research Background | BMAL2 is a 636 amino acid protein that localizes to the nucleus and contains one bHLH (basic helix-loop-helix) domain, one PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains. Expressed at high levels in placenta and brain and at lower levels in liver, thymus, heart, lung and kidney, BMAL2 functions as a component of the circadian core oscillator, which includes a variety of proteins that work in tandem to activate the transcription of target genes. More specifically, BMAL2, when functioning as a component of the core oscillator, binds to the E-box element (3'-CACGTG-5') of target DNA, thus inducing transcription. Multiple isoforms of BMAL2 exist due to alternative splicing events. |
Immunogen | KLH conjugated synthetic peptide: human ARNTL2 |
Antigen Species | Human |
Gene Name | ARNTL2 |
Gene ID | |
Protein Name | Aryl hydrocarbon receptor nuclear translocator-like protein 2 |
Uniprot ID | |
Biology Area | Cardiac metabolism,Transcription factors/regulators,HLH,Transcription Factors,Receptors |
Function | ARNTL2 (aryl hydrocarbon receptor nuclear translocator-like 2) is a basic Helix-Loop-Helix-Per-Arnt-Sim (bHLH-PAS) transcription factor. ARNTL2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription. Also, in umbilical vein endothelial cells, ARNTL2 activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1. It may participate in circadian clock regulation |
Molecular Weight | Theoretical: 71 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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