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VU-1545

Name: VU-1545
Brand: TargetMol
SKU: T23514
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T23514Cas No. 890764-63-3

Alias VU 1545

VU-1545 is mGlu5 positive allosteric modulator.

VU-1545

🥰Excellent

Purity: 98.8%

Catalog No. T23514Alias VU 1545Cas No. 890764-63-3

VU-1545 is mGlu5 positive allosteric modulator.

Pack Size	Price	Availability
1 mg	$35	In Stock
2 mg	$48	In Stock
5 mg	$83	In Stock
10 mg	$133	In Stock
25 mg	$257	In Stock
50 mg	$397	In Stock
100 mg	$572	In Stock
200 mg	$768	In Stock

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Questions

Batch Information

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Purity:98.8%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	VU-1545 is mGlu5 positive allosteric modulator.
Targets&IC50	mGluR5:9.6 nM (EC50), mGluR5:156 nM (Ki)
Synonyms	VU 1545

Chemical Properties

Molecular Weight	402.38
Formula	C₂₂H₁₅FN₄O₃
Cas No.	890764-63-3
Smiles	[O-][N+](=O)c1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1F)-c1ccccc1
Relative Density.	1.34 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (124.26 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4852 mL	12.4261 mL	24.8521 mL	124.2606 mL
5 mM	0.4970 mL	2.4852 mL	4.9704 mL	24.8521 mL
10 mM	0.2485 mL	1.2426 mL	2.4852 mL	12.4261 mL
20 mM	0.1243 mL	0.6213 mL	1.2426 mL	6.2130 mL
50 mM	0.0497 mL	0.2485 mL	0.4970 mL	2.4852 mL
100 mM	0.0249 mL	0.1243 mL	0.2485 mL	1.2426 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc