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VU-1545
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Catalog No. T23514Cas No. 890764-63-3
Alias VU 1545
VU-1545 is mGlu5 positive allosteric modulator.
VU-1545
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Purity: 98.8%
Catalog No. T23514Alias VU 1545Cas No. 890764-63-3
VU-1545 is mGlu5 positive allosteric modulator.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $38 | In Stock | In Stock | |
| 5 mg | $60 | In Stock | In Stock | |
| 10 mg | $81 | In Stock | In Stock | |
| 25 mg | $139 | In Stock | In Stock | |
| 50 mg | $226 | In Stock | In Stock | |
| 100 mg | $363 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.8%
Appearance:Solid
Color:Yellow
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Product Introduction
VU-1545 AI Summary
VU-1545 demonstrates significant bioactivities across a range of biological targets and systems. It shows notable affinity for the mGluR5 receptor, with a Ki value of 160.0 nM, suggesting competitive binding, and an EC50 value of 9.6 nM in enhancing glutamate-induced calcium flux in rat astrocytes, indicating its modulatory effect on receptor signaling. In addition to mGluR5, VU-1545 exhibits various biopotencies, including moderate activity in mitochondrial dynamics, lipid storage modulation, strong inhibition against AmpC Beta-Lactamase, ELG1-dependent DNA repair, and delayed death inhibition of the malarial parasite plastid. It also shows potential as an inhibitor of Nrf2, TGF-b, Hepatitis C Virus (HCV), GLP-1 receptor inverse agonist, human TDP1, and stage-specific inhibition of Vaccinia Orthopoxvirus.
In antiviral assays, VU-1545 inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 9.16% at 10 µM concentration after 48 hours and shows potential inhibition of SARS-CoV-2 3CL-Pro protease by -2.219% at 20 µM. It also demonstrates activity in reducing SARS-CoV-2 induced cytotoxicity in VERO-6 cells by 0.36% at 10 µM concentration after 48 hours.
Further, VU-1545 shows an inhibitory effect on human HDAC6 enzymatic activity, with 73.61% inhibition using a commercial peptide substrate. It impacts cell viability variably in HEK293T and U2OS cell lines, promoting growth, whereas it has mixed effects on human fibroblast cells. VU-1545 also affects the thermal stability of different molecular domains, either stabilizing or destabilizing them to varying extents.
Moreover, it is active in GPCR β-arrestin recruitment assays with multiple targets, including GPR119, APLNR, ADRB2, FPR2, GLP1R, CX3CR1, AGTR1, ADGRF1, S1PR1, C5AR1, FFAR4, GPR35, and ADRA2A, showing diverse levels of activation and inhibition. This broad spectrum of activity highlights VU-1545's potential as a versatile bioactive molecule with applications in various therapeutic areas..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | VU-1545 is mGlu5 positive allosteric modulator. |
| Targets&IC50 | mGluR5:9.6 nM (EC50), mGluR5:156 nM (Ki) |
| Synonyms | VU 1545 |
| Molecular Weight | 402.38 |
| Formula | C22H15FN4O3 |
| Cas No. | 890764-63-3 |
| Smiles | [O-][N+](=O)c1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1F)-c1ccccc1 |
| Relative Density. | 1.34 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (124.26 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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