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αvβ1 integrin-IN-1

Name: αvβ1 integrin-IN-1
Brand: TargetMol
SKU: T13473
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13473Cas No. 1689540-62-2

αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.

αvβ1 integrin-IN-1

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Purity: 99.69%

Catalog No. T13473Cas No. 1689540-62-2

αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	In Stock	In Stock
5 mg	$289	In Stock	In Stock
10 mg	$455	In Stock	In Stock
25 mg	$733	In Stock	In Stock
50 mg	$987	In Stock	In Stock
100 mg	$1,360	-	In Stock
200 mg	$1,830	-	In Stock
1 mL x 10 mM (in DMSO)	$355	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.69%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.
Targets&IC50	αvβ1 integrin:0.63 nM, αvβ1 integrin:0.63 nM
In vitro	In a murine model of liver and lung fibrosis, the administration of αvβ1 integrin-IN-1 leads to a significant reduction in the expression of fibrotic markers.[1]

Chemical Properties

Molecular Weight	558.65
Formula	C₂₆H₃₄N₆O₆S
Cas No.	1689540-62-2
Smiles	S(=O)(=O)(N1[C@H](C(N[C@@H](CC2=CC=C(NC(CCCCNC(=N)N)=O)C=C2)C(O)=O)=O)CCC1)C3=CC=CC=C3
Relative Density.	1.42 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (447.51 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (8.95 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7900 mL	8.9501 mL	17.9003 mL	89.5015 mL
5 mM	0.3580 mL	1.7900 mL	3.5801 mL	17.9003 mL
10 mM	0.1790 mL	0.8950 mL	1.7900 mL	8.9501 mL
20 mM	0.0895 mL	0.4475 mL	0.8950 mL	4.4751 mL
50 mM	0.0358 mL	0.1790 mL	0.3580 mL	1.7900 mL
100 mM	0.0179 mL	0.0895 mL	0.1790 mL	0.8950 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc