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BILB-1941

Name: BILB-1941
Brand: TargetMol
SKU: T26815
Price: 329 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26815Cas No. 494856-61-0

Alias BILB-1941ZW, BILB1941ZW, BILB 1941ZW

BILB-1941 (BILB-1941ZW) is an inhibitor of HCV NS5B polymerase and can be used in studies about HCV infection.

BILB-1941

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Purity: 99.65%

Catalog No. T26815Alias BILB-1941ZW, BILB1941ZW, BILB 1941ZWCas No. 494856-61-0

BILB-1941 (BILB-1941ZW) is an inhibitor of HCV NS5B polymerase and can be used in studies about HCV infection.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$329	In Stock	In Stock
5 mg	$798	In Stock	In Stock
10 mg	$1,090	In Stock	In Stock
25 mg	$1,650	In Stock	In Stock
50 mg	$2,230	-	In Stock
100 mg	$2,930	-	In Stock
1 mL x 10 mM (in DMSO)	$1,160	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.65%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

BILB-1941 AI Summary

BILB-1941 exhibits a broad range of bioactivities, including antiviral activity against Hepatitis C virus (HCV) genotypes 1a and 1b, with EC50 values of 153.0 nM and 84.0 nM, respectively. It shows inhibition of HCV genotype 1b NS5B polymerase with an IC50 of 60.0 nM and demonstrates moderate to high oral bioavailability in animal models (rhesus monkey, dog, and rat) with half-lives ranging from 1.5 to 4.3 hours. The compound also inhibits specific CYP enzymes (CYP3A4 and CYP2C19) with IC50 values of 9500.0 nM and 2900.0 nM, respectively, and exhibits moderate permeability across human Caco2 cells. Additionally, it has significant binding to plasma proteins (99.2% in humans) and demonstrates various enzyme inhibitions including MAO-A, dopamine D1 receptor, glucocorticoid receptor, COX2, cathepsin G, 5-LO, GABAA receptor, and alpha2A adrenergic receptor, all with IC50 values under 10000.0 nM. BILB-1941's diverse pharmacokinetic parameters and enzyme interactions suggest its potential as a multifaceted antiviral agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	BILB-1941 (BILB-1941ZW) is an inhibitor of HCV NS5B polymerase and can be used in studies about HCV infection.
Synonyms	BILB-1941ZW, BILB1941ZW, BILB 1941ZW

Chemical Properties

Molecular Weight	562.66
Formula	C₃₄H₃₄N₄O₄
Cas No.	494856-61-0
Smiles	CN1C(=C(C=2C1=CC(C(NC3(C(NC4=CC=C(/C=C/C(O)=O)C=C4)=O)CCC3)=O)=CC2)C5CCCC5)C6=CC=CC=N6
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (88.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7773 mL	8.8864 mL	17.7727 mL	88.8636 mL
5 mM	0.3555 mL	1.7773 mL	3.5545 mL	17.7727 mL
10 mM	0.1777 mL	0.8886 mL	1.7773 mL	8.8864 mL
20 mM	0.0889 mL	0.4443 mL	0.8886 mL	4.4432 mL
50 mM	0.0355 mL	0.1777 mL	0.3555 mL	1.7773 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc