CD93/C1qR1 Protein, Human, Recombinant (hFc)

Catalog No. TMPY-02262

CD93/C1qR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 85.2 kDa and the accession number is Q9NPY3.

CD93/C1qR1 Protein, Human, Recombinant (hFc)

Catalog No. TMPY-02262

CD93/C1qR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 85.2 kDa and the accession number is Q9NPY3.

Pack Size	Price	Availability
5 μg	$93	7-10 days
10 μg	$152	7-10 days
20 μg	$248	7-10 days
50 μg	$498	7-10 days
100 μg	$858	7-10 days
200 μg	$1,530	7-10 days
500 μg	$3,790	7-10 days

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Product Information

Biological Activity	Immobilized Human IGFBP7 (His Tag) at 2 μg/ml (100 μl/well) can bind Human CD93 (hFc Tag). The EC50 is 15-120 ng/ml.
Description	CD93/C1qR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 85.2 kDa and the accession number is Q9NPY3.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	Q9NPY3
Synonyms	MXRA4,ECSM3,dJ737E23.1,CDw93,CD93 molecule,C1qRP,C1QR1,C1qR(P),C1qR
Construction	A DNA sequence encoding the human CD93 (Q9NPY3) extracellular domain (Met 1-Lys 580) was fused with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Thr 22
Protein Purity	> 85 % as determined by SDS-PAGE
Molecular Weight	85.2 kDa (predicted); 125 kDa (reducing condition, due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protein expressed on monocytes, neutrophils, endothelial cells, and stem cells. CD93 was originally identified as a myeloid cell-surface marker and subsequently associated with an ability to modulate phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro. CD93/C1qR, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. CD93 is important for the maintenance of plasma cells in bone marrow niches.