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Senexin C

Name: Senexin C
Brand: TargetMol
SKU: T62702
Price: 188 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T62702Cas No. 2375554-02-0

Senexin C is a novel orally active and specific CDK8/19 inhibitor with potential anticancer activity.Senexin C is more metabolically stable and potent than Senexin B. Senexin C inhibits the growth of MV4-11 leukaemia cells.

Senexin C

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Purity: 98.06%

Catalog No. T62702Cas No. 2375554-02-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$188	-	In Stock
5 mg	$478	-	In Stock
10 mg	$698	-	In Stock
1 mL x 10 mM (in DMSO)	$528	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.06%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Senexin C is a novel orally active and specific CDK8/19 inhibitor with potential anticancer activity.Senexin C is more metabolically stable and potent than Senexin B. Senexin C inhibits the growth of MV4-11 leukaemia cells.
Targets&IC50	CDK8-CyclinC:3.6 nM, CDK8-CyclinC:1.4 nM (Kd), CDK8-CyclinC:2.9 nM (Kd)
In vitro	Senexin C exhibits high selectivity for CDK8 and CDK19, with similar Kd values of 55 nM and 44 nM respectively for ATP analog binding, while showing much higher Kd values for the other three non-target kinases (HASPIN: 1000 nM; MAP4K2: 940 nM; MYO3B: > 30,000 nM)[1].
In vivo	Tumor-bearing mice（CT26 tumor mode） received Senexin C via intravenous injection at 2.5 mg/kg or orally at 100 mg/kg, and compound concentrations in blood and tumors were measured by LC-MS/MS. The results indicated that Senexin C exhibits favorable tumor PK characteristics and low toxicity[1].

Chemical Properties

Molecular Weight	449.55
Formula	C₂₈H₂₇N₅O
Cas No.	2375554-02-0
Smiles	N#CC=1C=CC2=NC=CC(NCCC=3C=CC4=CC(=CC=C4C3)C(=O)N5CCN(C)CC5)=C2C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (44.49 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+90% Saline: 2 mg/mL (4.45 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2244 mL	11.1222 mL	22.2445 mL	111.2223 mL
5 mM	0.4449 mL	2.2244 mL	4.4489 mL	22.2445 mL
10 mM	0.2224 mL	1.1122 mL	2.2244 mL	11.1222 mL
20 mM	0.1112 mL	0.5561 mL	1.1122 mL	5.5611 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc