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PD 144418 oxalate
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Catalog No. T39211Cas No. 1794760-28-3
PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand with a Ki value of 0.08 nM for σ1 and 1377 nM for σ2, exhibiting negligible affinity for other receptors, ion channels, and enzymes, and demonstrating potential antipsychotic activity.
PD 144418 oxalate
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Purity: 98.76%
Catalog No. T39211Cas No. 1794760-28-3
PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand with a Ki value of 0.08 nM for σ1 and 1377 nM for σ2, exhibiting negligible affinity for other receptors, ion channels, and enzymes, and demonstrating potential antipsychotic activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $54 | - | In Stock | |
| 5 mg | $135 | - | In Stock | |
| 10 mg | $196 | - | In Stock | |
| 25 mg | $338 | - | In Stock | |
| 50 mg | $492 | - | In Stock | |
| 100 mg | $719 | - | In Stock | |
| 200 mg | $987 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.76%
Appearance:Solid
Color:Yellow
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand with a Ki value of 0.08 nM for σ1 and 1377 nM for σ2, exhibiting negligible affinity for other receptors, ion channels, and enzymes, and demonstrating potential antipsychotic activity. |
| Targets&IC50 | σ1 receptor:0.08 nM (Ki), σ2 receptor:1377 nM (Ki) |
| In vitro | In vitro, PD 144418 counteracts the increase in cyclic GMP (cGMP) triggered by N-methyl-D-aspartate (NMDA) in rat cerebellar slices, without altering basal levels. This implies a significant role for σ1 sites in controlling actions induced by glutamine. Furthermore, PD 144418 enhances the reduction of 5-hydroxytryptophan induced by Haloperidol within the mesolimbic region, although it does not independently affect 5-HT and dopamine (DA) synthesis [1]. |
| In vivo | Treatment with PD 144418 (10 mg/kg; intraperitoneal injection; male CD-1 mice) effectively antagonized Mescaline-induced scratching without affecting spontaneous motor activity, displaying an ED 50 of 7.0 mg/kg (i.p.). This outcome was observed in a study where male CD-1 mice were administered a single intraperitoneal dose of 10 mg/kg, resulting in the inhibition of scratching behaviors induced by Mescaline. |
| Molecular Weight | 372.42 |
| Formula | C20H24N2O5 |
| Cas No. | 1794760-28-3 |
| Smiles | O=C(O)C(=O)O.N=1OC(=CC1C=2C=CC(=CC2)C)C3=CCCN(C3)CCC |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (26.85 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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