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Anti-NEDD4-2 Antibody (3Y211)
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Catalog No. TMAB-09336
Anti-NEDD4-2 Antibody (3Y211) is a Rabbit antibody targeting NEDD4-2. Anti-NEDD4-2 Antibody (3Y211) can be used in WB, IP.
Anti-NEDD4-2 Antibody (3Y211)
Anti-NEDD4-2 Antibody (3Y211)
😃Good
Catalog No. TMAB-09336
Anti-NEDD4-2 Antibody (3Y211) is a Rabbit antibody targeting NEDD4-2. Anti-NEDD4-2 Antibody (3Y211) can be used in WB, IP.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $149 | 7-10 days | 7-10 days | |
| 50 μL | $262 | 7-10 days | 7-10 days | |
| 100 μL | $470 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-NEDD4-2 Antibody (3Y211) is a Rabbit antibody targeting NEDD4-2. Anti-NEDD4-2 Antibody (3Y211) can be used in WB, IP. |
| Ig Type | IgG |
| Clone | 3Y211 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-2000; IP: 1:20-50 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. May be recruited to exosomes by NDFIP1. |
| Tissue Specificity | Ubiquitously expressed, with highest levels in prostate, pancreas and kidney. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair. |
| Immunogen | A synthesized peptide: human NEDD4L |
| Antigen Species | Human |
| Gene Name | NEDD4L |
| Gene ID | |
| Protein Name | E3 ubiquitin-protein ligase NEDD4-like |
| Uniprot ID | |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. |
| Molecular Weight | Theoretical: 112 kDa. Actual: 130 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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