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CC-90001

Name: CC-90001
Brand: TargetMol
SKU: T9688
Price: 77 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9688Cas No. 1403859-14-2

CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.

CC-90001

🥰Excellent

Purity: 99.96%

Catalog No. T9688Cas No. 1403859-14-2

CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$77	In Stock	In Stock
5 mg	$156	In Stock	In Stock
10 mg	$235	In Stock	In Stock
25 mg	$423	In Stock	In Stock
50 mg	$593	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$169	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.96%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.
In vitro	CC-90001 is 12.9-fold more potent for JNK1 inhibition over JNK2 in knockout fibroblasts[1]. CC-90001 blocks LPS-induced c-jun phosphorylation (EC50 = 480 nM)[2].
In vivo	CC-90001 effectively mitigates lung fibrosis by significantly decreasing lung collagen metrics and lowering disease-induced α-SMA increases to nearly baseline levels in a house dust mite-induced lung fibrosis model. Moreover, when administered at a dosage of 3 mg/kg b.i.d., it hampers fibrosis development, evidenced by a notable reduction of 48% in collagen and 53% in α-smooth muscle actin (α-SMA) within a steatohepatitis model.

Chemical Properties

Molecular Weight	321.42
Formula	C₁₆H₂₇N₅O₂
Cas No.	1403859-14-2
Smiles	C[C@@H]1CC[C@H](C[C@H]1O)Nc1nc(NC(C)(C)C)ncc1C(N)=O
Relative Density.	1.224 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (388.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.44 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1112 mL	15.5560 mL	31.1119 mL	155.5597 mL
5 mM	0.6222 mL	3.1112 mL	6.2224 mL	31.1119 mL
10 mM	0.3111 mL	1.5556 mL	3.1112 mL	15.5560 mL
20 mM	0.1556 mL	0.7778 mL	1.5556 mL	7.7780 mL
50 mM	0.0622 mL	0.3111 mL	0.6222 mL	3.1112 mL
100 mM	0.0311 mL	0.1556 mL	0.3111 mL	1.5556 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc