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Verucerfont

Name: Verucerfont
Brand: TargetMol
SKU: T7361
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7361Cas No. 885220-61-1

Alias NBI77860, GSK561679

Verucerfont (NBI77860) is an antagonist of corticotropin-releasing factor receptor 1 (CRF1) .

Verucerfont

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Purity: 99.90%

Catalog No. T7361Alias NBI77860, GSK561679Cas No. 885220-61-1

Verucerfont (NBI77860) is an antagonist of corticotropin-releasing factor receptor 1 (CRF1) .

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$58	In Stock	In Stock
2 mg	$84	In Stock	In Stock
5 mg	$139	In Stock	In Stock
10 mg	$228	In Stock	In Stock
25 mg	$418	In Stock	In Stock
50 mg	$637	In Stock	In Stock
100 mg	$893	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$153	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.90%

Color:White

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	Verucerfont (NBI77860) is an antagonist of corticotropin-releasing factor receptor 1 (CRF1) .
Targets&IC50	CRF2:1000 nM, CRF1:~6.1nM, CRF-BP:>1000 nM
In vivo	Verucerfont potently blocked the HPA axis response to the dexamethasone-CRF test, but left alcohol craving unaffected.?Right amygdala responses to negative affective stimuli were significantly attenuated by verucerfont, but responses to alcohol-associated stimuli were increased in some brain regions, including left insula[1].
Synonyms	NBI77860, GSK561679

Chemical Properties

Molecular Weight	406.48
Formula	C₂₂H₂₆N₆O₂
Cas No.	885220-61-1
Smiles	CC[C@H](Nc1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1C)c1nc(C)no1
Relative Density.	1.29 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 86.7 mg/mL (213.29 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4601 mL	12.3007 mL	24.6015 mL	123.0073 mL
5 mM	0.4920 mL	2.4601 mL	4.9203 mL	24.6015 mL
10 mM	0.2460 mL	1.2301 mL	2.4601 mL	12.3007 mL
20 mM	0.1230 mL	0.6150 mL	1.2301 mL	6.1504 mL
50 mM	0.0492 mL	0.2460 mL	0.4920 mL	2.4601 mL
100 mM	0.0246 mL	0.1230 mL	0.2460 mL	1.2301 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc