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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | Androgen receptor antagonist 1, an orally available full androgen receptor antagonist (IC50: 59 nM), is utilized in the synthesis of PROTAC AR degraders, achieving 24% and 47% AR protein degradation in LNCaP cells at concentrations of 1 μM and 10 μM, respectively. |
Targets&IC50 | Androgen receptor:59 nM |
In vitro | Androgen receptor antagonist 1 (Compound 26; 1 nM-100 μM) demonstrates significant cell growth inhibition in LNAR and LNCaP cells, but not in DU145 cells [1]. |
In vivo | Androgen receptor antagonist 1 (100 mg/kg once a day for 5 weeks) shows excellent in vivo tumor growth inhibition upon oral administration in castration-resistant prostate cancer (CRPC) animal model [1]. |
Molecular Weight | 416.9 |
Formula | C21H25ClN4O3 |
Cas No. | 1338812-36-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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