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Anti-Phospho-EGFR (S695) Antibody (1J343)

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Catalog No. TMAC-03207

Anti-Phospho-EGFR (S695) Antibody (1J343) is a Rabbit antibody targeting Phospho-EGFR (S695). Anti-Phospho-EGFR (S695) Antibody (1J343) can be used in WB,ICC/IF.

Anti-Phospho-EGFR (S695) Antibody (1J343)

Anti-Phospho-EGFR (S695) Antibody (1J343)

😃Good
Catalog No. TMAC-03207
Anti-Phospho-EGFR (S695) Antibody (1J343) is a Rabbit antibody targeting Phospho-EGFR (S695). Anti-Phospho-EGFR (S695) Antibody (1J343) can be used in WB,ICC/IF.
Pack SizePriceAvailabilityQuantity
50 μL$2977-10 days
100 μL$4987-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-EGFR (S695) Antibody (1J343) is a Rabbit antibody targeting Phospho-EGFR (S695). Anti-Phospho-EGFR (S695) Antibody (1J343) can be used in WB,ICC/IF.
Ig Type
IgG
Reactivity
Human
Application
Recommended Dose
WB: 1:1000; ICC/IF: 1:100-500
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundThe EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Exons in the EGFR gene product are frequently either deleted or duplicated to produce deletion mutants (DM) or tandem duplication mutants (TDM), respectively, which are detected at various molecular weights. EGFR binds several ligands, including epidermal growth factor (EGF), transforming growth factor α (TGFα), Amphiregulin and heparin binding-EGF (HB-EGF). Ligand binding promotes the internalization of EGFR via Clathrin-coated pits and its subsequent degradation in response to its intrinsic tyrosine kinase. EGFR is involved in organ morphogenesis and maintenance and repair of tissues, but upregulation of EGFR is associated with tumor progression. The oncogenic effects of EGFR include initiation of DNA synthesis, enhanced cell growth, invasion and metastasis. Abrogation of EGFR results in cell cycle arrest, apoptosis or dedifferentiation of cancer cells, suggesting that EGFR may be an effective therapeutic target.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
A synthesized phosphopeptide: human EGFR around the phosphorylation site of Ser695
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 134 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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