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Anti-Phospho-EGFR (S695) Antibody (1J343)
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Catalog No. TMAC-03207
Anti-Phospho-EGFR (S695) Antibody (1J343) is a Rabbit antibody targeting Phospho-EGFR (S695). Anti-Phospho-EGFR (S695) Antibody (1J343) can be used in WB,ICC/IF.
Anti-Phospho-EGFR (S695) Antibody (1J343)
Anti-Phospho-EGFR (S695) Antibody (1J343)
😃Good
Catalog No. TMAC-03207
Anti-Phospho-EGFR (S695) Antibody (1J343) is a Rabbit antibody targeting Phospho-EGFR (S695). Anti-Phospho-EGFR (S695) Antibody (1J343) can be used in WB,ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $297 | 7-10 days | |
| 100 μL | $498 | 7-10 days |
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| Description | Anti-Phospho-EGFR (S695) Antibody (1J343) is a Rabbit antibody targeting Phospho-EGFR (S695). Anti-Phospho-EGFR (S695) Antibody (1J343) can be used in WB,ICC/IF. |
| Ig Type | IgG |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:1000; ICC/IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Exons in the EGFR gene product are frequently either deleted or duplicated to produce deletion mutants (DM) or tandem duplication mutants (TDM), respectively, which are detected at various molecular weights. EGFR binds several ligands, including epidermal growth factor (EGF), transforming growth factor α (TGFα), Amphiregulin and heparin binding-EGF (HB-EGF). Ligand binding promotes the internalization of EGFR via Clathrin-coated pits and its subsequent degradation in response to its intrinsic tyrosine kinase. EGFR is involved in organ morphogenesis and maintenance and repair of tissues, but upregulation of EGFR is associated with tumor progression. The oncogenic effects of EGFR include initiation of DNA synthesis, enhanced cell growth, invasion and metastasis. Abrogation of EGFR results in cell cycle arrest, apoptosis or dedifferentiation of cancer cells, suggesting that EGFR may be an effective therapeutic target. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | A synthesized phosphopeptide: human EGFR around the phosphorylation site of Ser695 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Theoretical: 134 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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