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Specific PXR antagonist 70

🥰Excellent
Catalog No. T41255Cas No. 931314-31-7

Specific PXR antagonist 70 is a selective pregnane X receptor (PXR) antagonist with an IC50 of 540 nM and Ki of 390 nM for human PCR and enhances the chemosensitivity of cancer cells.

Specific PXR antagonist 70

Specific PXR antagonist 70

🥰Excellent
Purity: 98.41%
Catalog No. T41255Cas No. 931314-31-7
Specific PXR antagonist 70 is a selective pregnane X receptor (PXR) antagonist with an IC50 of 540 nM and Ki of 390 nM for human PCR and enhances the chemosensitivity of cancer cells.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$48In StockIn Stock
5 mg$106In StockIn Stock
10 mg$147In StockIn Stock
25 mg$239In StockIn Stock
50 mg$372In StockIn Stock
100 mg$538In StockIn Stock
500 mg$1,150-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:98.41%
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Product Introduction

Bioactivity
Description
Specific PXR antagonist 70 is a selective pregnane X receptor (PXR) antagonist with an IC50 of 540 nM and Ki of 390 nM for human PCR and enhances the chemosensitivity of cancer cells.
Chemical Properties
Molecular Weight415.51
FormulaC21H25N3O4S
Cas No.931314-31-7
SmilesCOC1=CC=C(OC)C(=C1)N1N=NC(=C1C)S(=O)(=O)C1=CC=C(C=C1)C(C)(C)C
Relative Density.1.22 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 76.92 mg/mL (210 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM2.4067 mL12.0334 mL24.0668 mL120.3340 mL
5 mM0.4813 mL2.4067 mL4.8134 mL24.0668 mL
10 mM0.2407 mL1.2033 mL2.4067 mL12.0334 mL
20 mM0.1203 mL0.6017 mL1.2033 mL6.0167 mL
50 mM0.0481 mL0.2407 mL0.4813 mL2.4067 mL
100 mM0.0241 mL0.1203 mL0.2407 mL1.2033 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Specific PXR antagonist 70PXRpregnane X receptorInhibitorinhibithPXRcancer
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