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Meclocycline sulfosalicylate salt
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Catalog No. T0281Cas No. 73816-42-9
Alias Meclutin, Mecloderm, Meclan Cream
Meclocycline sulfosalicylate salt (Mecloderm), a tetracycline antibiotic, is used topically (i.e. for skin infections) as it is totally insoluble in water and may damage kidney and liver if given systemically.
Meclocycline sulfosalicylate salt
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Purity: 99.07%
Catalog No. T0281Alias Meclutin, Mecloderm, Meclan CreamCas No. 73816-42-9
Meclocycline sulfosalicylate salt (Mecloderm), a tetracycline antibiotic, is used topically (i.e. for skin infections) as it is totally insoluble in water and may damage kidney and liver if given systemically.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $33 | In Stock | In Stock | |
| 25 mg | $52 | In Stock | In Stock | |
| 50 mg | $74 | In Stock | In Stock | |
| 100 mg | $108 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.07%
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Product Introduction
Meclocycline sulfosalicylate salt AI Summary
Meclocycline sulfosalicylate salt inhibits synthetic amyloid beta-42 fibrillation, reducing it by 7.6% compared to control in ThT fluorescence analysis and has an IC50 value of 250.0 nM for inhibiting amyloid beta-42 oligomerization in an ELISA assay. It exhibits inhibitory activity in several cellular assays, including a potency of 11374.3 nM against human tyrosyl-DNA phosphodiesterase 1 (TDP1) without CPT, 12762.2 nM against TDP1 with CPT, and 11220.2 nM against Human Apurinic/apyrimidinic Endonuclease 1 (APE1). It also shows a potency of 891.3 nM against Marburg Virus entry into cells. Additionally, Meclocycline sulfosalicylate salt inhibits sodium fluorescein uptake in OATP1B3-transfected CHO cells by 107.82% and in OATP1B1-transfected CHO cells by 122.12% at 10 µM concentration. It has shown antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells with a hit score of 0.1338, indicating moderate activity in inhibiting the virus..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Meclocycline sulfosalicylate salt (Mecloderm), a tetracycline antibiotic, is used topically (i.e. for skin infections) as it is totally insoluble in water and may damage kidney and liver if given systemically. |
| Synonyms | Meclutin, Mecloderm, Meclan Cream |
| Molecular Weight | 695.05 |
| Formula | C22H21ClN2O8·C7H6O6S |
| Cas No. | 73816-42-9 |
| Smiles | OC(=O)c1cc(ccc1O)S(O)(=O)=O.[H][C@@]12[C@@H](O)[C@]3([H])C(=C)c4c(Cl)ccc(O)c4C(=O)C3=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 150 mg/mL (215.81 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (5.75 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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