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Anti-CYP3A4 Antibody (2B571)
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Catalog No. TMAH-00329
Alias sulfoxide-forming, Quinine 3-monooxygenase, Nifedipine oxidase, Cytochrome P450-PCN1, Cytochrome P450 NF-25, Cytochrome P450 HLp, Cytochrome P450 3A4, Cytochrome P450 3A3, CYPIIIA4, CYPIIIA3, CYP3A3, Cholesterol 25-hydroxylase, Albendazole sulfoxidase, Albendazole monooxygenase, 1,8-cineole 2-exo-monooxygenase, 1,4-cineole 2-exo-monooxygenase
Anti-CYP3A4 Antibody (2B571) is an antibody targeting CYP3A4. Anti-CYP3A4 Antibody (2B571) can be used in ELISA, IHC.
Anti-CYP3A4 Antibody (2B571)
Anti-CYP3A4 Antibody (2B571)
😃Good
Catalog No. TMAH-00329Alias sulfoxide-forming, Quinine 3-monooxygenase, Nifedipine oxidase, Cytochrome P450-PCN1, Cytochrome P450 NF-25, Cytochrome P450 HLp, Cytochrome P450 3A4, Cytochrome P450 3A3, CYPIIIA4, CYPIIIA3, CYP3A3, Cholesterol 25-hydroxylase, Albendazole sulfoxidase, Albendazole monooxygenase, 1,8-cineole 2-exo-monooxygenase, 1,4-cineole 2-exo-monooxygenase
Anti-CYP3A4 Antibody (2B571) is an antibody targeting CYP3A4. Anti-CYP3A4 Antibody (2B571) can be used in ELISA, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $207 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
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Chemical Properties
| Description | Anti-CYP3A4 Antibody (2B571) is an antibody targeting CYP3A4. Anti-CYP3A4 Antibody (2B571) can be used in ELISA, IHC. |
| Alias | sulfoxide-forming, Quinine 3-monooxygenase, Nifedipine oxidase, Cytochrome P450-PCN1, Cytochrome P450 NF-25, Cytochrome P450 HLp, Cytochrome P450 3A4, Cytochrome P450 3A3, CYPIIIA4, CYPIIIA3, CYP3A3, Cholesterol 25-hydroxylase, Albendazole sulfoxidase, Albendazole monooxygenase, 1,8-cineole 2-exo-monooxygenase, 1,4-cineole 2-exo-monooxygenase |
| Ig Type | Rabbit IgG |
| Clone | 2B571 |
| Reactivity | Human |
| Verified Activity | 1. IHC image of TMAH-00329 diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. 2. IHC image of TMAH-00329 diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| Application | ELISA, IHC |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position. Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone. Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones. Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis. Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond. Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling. Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance. Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole. Hydroxylates antimalarial drug quinine. Acts as a 1,4-cineole 2-exo-monooxygenase. Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)). |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Cytochrome P450 3A4 |
| Antigen Species | Human |
| Gene ID | 1576 |
| Uniprot ID | |
| Biology Area | Cancer, Cardiovascular, Metabolism, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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