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mTOR inhibitor-1

🥰Excellent
Catalog No. T5338Cas No. 468747-17-3

C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.

mTOR inhibitor-1

mTOR inhibitor-1

🥰Excellent
Purity: 99.43%
Catalog No. T5338Cas No. 468747-17-3
C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$34In StockIn Stock
5 mg$55In StockIn Stock
10 mg$93In StockIn Stock
25 mg$189In StockIn Stock
50 mg$297In StockIn Stock
100 mg$493In StockIn Stock
1 mL x 10 mM (in DMSO)$61In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.43%
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Product Introduction

Bioactivity
Description
C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.
In vitro
The addition of C-4 (mTOR inhibitor-1, 0~12.8 μg/ml) directly decreases the level of activated mTOR (p-mTORser2448) which is phosphorylated at Ser2448. The proliferation of A549 cells is strongly inhibited by C-4, and the inhibitory effect is time- and dose314 dependent. The IC50 of C-4 at 24 h is calculated as 3.176 μM.
Chemical Properties
Molecular Weight363.21
FormulaC16H15BrN2O3
Cas No.468747-17-3
SmilesC\C(=N/NC(=O)c1ccc(C)c(Br)c1)c1ccc(O)cc1O
Relative Density.1.48 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 70 mg/mL (192.73 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.51 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7532 mL13.7661 mL27.5323 mL137.6614 mL
5 mM0.5506 mL2.7532 mL5.5065 mL27.5323 mL
10 mM0.2753 mL1.3766 mL2.7532 mL13.7661 mL
20 mM0.1377 mL0.6883 mL1.3766 mL6.8831 mL
50 mM0.0551 mL0.2753 mL0.5506 mL2.7532 mL
100 mM0.0275 mL0.1377 mL0.2753 mL1.3766 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

mTOR inhibitor-1mTOR inhibitor1mTOR inhibitor 1mTORMammalian target of RapamycinInhibitorinhibitAutophagy
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