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mTOR inhibitor-1

Name: mTOR inhibitor-1
Brand: TargetMol
SKU: T5338
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T5338Cas No. 468747-17-3

C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.

mTOR inhibitor-1

🥰Excellent

Purity: 99.43%

Catalog No. T5338Cas No. 468747-17-3

C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.

Pack Size	Price	Availability
2 mg	$34	In Stock
5 mg	$55	In Stock
10 mg	$93	In Stock
25 mg	$189	In Stock
50 mg	$297	In Stock
100 mg	$493	In Stock
1 mL x 10 mM (in DMSO)	$61	In Stock

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Batch Information

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Purity:99.43%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.
In vitro	The addition of C-4 (mTOR inhibitor-1, 0~12.8 μg/ml) directly decreases the level of activated mTOR (p-mTORser2448) which is phosphorylated at Ser2448. The proliferation of A549 cells is strongly inhibited by C-4, and the inhibitory effect is time- and dose314 dependent. The IC50 of C-4 at 24 h is calculated as 3.176 μM.

Chemical Properties

Molecular Weight	363.21
Formula	C₁₆H₁₅BrN₂O₃
Cas No.	468747-17-3
Smiles	C\C(=N/NC(=O)c1ccc(C)c(Br)c1)c1ccc(O)cc1O
Relative Density.	1.48 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 70 mg/mL (192.73 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7532 mL	13.7661 mL	27.5323 mL	137.6614 mL
5 mM	0.5506 mL	2.7532 mL	5.5065 mL	27.5323 mL
10 mM	0.2753 mL	1.3766 mL	2.7532 mL	13.7661 mL
20 mM	0.1377 mL	0.6883 mL	1.3766 mL	6.8831 mL
50 mM	0.0551 mL	0.2753 mL	0.5506 mL	2.7532 mL
100 mM	0.0275 mL	0.1377 mL	0.2753 mL	1.3766 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc