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GYKI-47261 dihydrochloride
🥰Excellent
Catalog No. T38601Cas No. 1217049-32-5
Alias GYKI47261 dihydrochloride
GYKI-47261 dihydrochloride is an orally active and selective AMPA receptor antagonist, also a CYP2E1 inducer with broad anticonvulsant and neuroprotective activity, used in neurological and cardiovascular research.
GYKI-47261 dihydrochloride
🥰Excellent
Purity: 99.14%
Catalog No. T38601Alias GYKI47261 dihydrochlorideCas No. 1217049-32-5
GYKI-47261 dihydrochloride is an orally active and selective AMPA receptor antagonist, also a CYP2E1 inducer with broad anticonvulsant and neuroprotective activity, used in neurological and cardiovascular research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $718 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,520 | In Stock |
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Purity:99.14%
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Product Introduction
Bioactivity
Chemical Properties
| Description | GYKI-47261 dihydrochloride is an orally active and selective AMPA receptor antagonist, also a CYP2E1 inducer with broad anticonvulsant and neuroprotective activity, used in neurological and cardiovascular research. |
| Targets&IC50 | AMPA:2.5 μM |
| In vitro | GYKI-47261 dihydrochloride inhibits AMPA or rhodosine-induced whole cell currents in isolated neurons. [1] |
| In vivo | GYKI-47261 dihydrochloride (200 mg/kg orally) is highly active in transient focal ischemia models. Antiischemic effect of GYKI-47261 dihydrochloride (6 mg/kg iv) in rats with transient focal cerebral ischemia. GYKI-47261 dihydrochloride effectively alleviates tremor induced by oxotremorine, a cholinergic agonist, in the treatment of Parkinson's disease. [1] |
| Synonyms | GYKI47261 dihydrochloride |
| Molecular Weight | 395.71 |
| Formula | C18H17Cl3N4 |
| Cas No. | 1217049-32-5 |
| Smiles | ClC1=CC(C(C2=CC=C(N)C=C2)=NN3C=C(C)N=C3C4)=C4C=C1.Cl.Cl |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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