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TLR3-IN-1

Name: TLR3-IN-1
Brand: TargetMol
SKU: T22698
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T22698Cas No. 1279713-77-7

Alias CU CPT 4a

TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cells.

TLR3-IN-1

🥰Excellent

Purity: 98.56%

Catalog No. T22698Alias CU CPT 4aCas No. 1279713-77-7

Pack Size	Price	Availability
1 mg	$46	In Stock
5 mg	$110	In Stock
10 mg	$187	In Stock
25 mg	$397	In Stock
50 mg	$593	In Stock
100 mg	$845	In Stock
200 mg	$1,150	In Stock
1 mL x 10 mM (in DMSO)	$122	In Stock

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Batch Information

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Purity:98.56%

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cells.
Targets&IC50	TLR3:3.44 μM (in RAW 264.7 cells)
Synonyms	CU CPT 4a

Chemical Properties

Molecular Weight	377.82
Formula	C₁₈H₁₃ClFNO₃S
Cas No.	1279713-77-7
Smiles	OC(=O)[C@@H](Cc1ccccc1)NC(=O)c1sc2cc(F)ccc2c1Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (132.34 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6468 mL	13.2338 mL	26.4676 mL	132.3382 mL
5 mM	0.5294 mL	2.6468 mL	5.2935 mL	26.4676 mL
10 mM	0.2647 mL	1.3234 mL	2.6468 mL	13.2338 mL
20 mM	0.1323 mL	0.6617 mL	1.3234 mL	6.6169 mL
50 mM	0.0529 mL	0.2647 mL	0.5294 mL	2.6468 mL
100 mM	0.0265 mL	0.1323 mL	0.2647 mL	1.3234 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc