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Anti-Coagulation factor X/F10 Antibody (1Q361)
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Catalog No. TMAY-01599
Alias FXA, FX, coagulation factor X, coagulation factor 10
Anti-Coagulation factor X/F10 Antibody (1Q361) is a Mouse antibody targeting Coagulation factor X/F10. Anti-Coagulation factor X/F10 Antibody (1Q361) can be used in IHC-P.
Anti-Coagulation factor X/F10 Antibody (1Q361)
Anti-Coagulation factor X/F10 Antibody (1Q361)
😃Good
Catalog No. TMAY-01599Alias FXA, FX, coagulation factor X, coagulation factor 10
Anti-Coagulation factor X/F10 Antibody (1Q361) is a Mouse antibody targeting Coagulation factor X/F10. Anti-Coagulation factor X/F10 Antibody (1Q361) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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| Description | Anti-Coagulation factor X/F10 Antibody (1Q361) is a Mouse antibody targeting Coagulation factor X/F10. Anti-Coagulation factor X/F10 Antibody (1Q361) can be used in IHC-P. |
| Alias | FXA, FX, coagulation factor X, coagulation factor 10 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 1Q361 |
| Reactivity | Human |
| Verified Activity | Immunochemical staining of human FX in human cirrhosis with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:50-1:200 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Coagulation Factor X / F10 (rh Coagulation Factor X / F10; TMPY-01101; NP_000495.1; Met1-Lys488). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the coagulation cascade and blood clotting, as the first enzyme in the common pathway of thrombus formation. Factor X deficiency is one of the rarest of the inherited coagulation disorders. FX deficiency among the most severe of the rare coagulation defects, typically including hemarthroses, hematomas, and umbilical cord, gastrointestinal, and central nervous system bleeding. Factor X is synthesized in the liver as a mature heterodimer formed from a single-chain precursor, and vitamin K is essential for its synthesis. Factor X is activated into factor Xa (FXa) by both factor IX (with its cofactor, factor VIII in a complex known as intrinsic Xase) and factor VII (with its cofactor, tissue factor in a complex known as extrinsic Xase) through cleaving the activation propeptide. As the first member of the final common pathway or thrombin pathway, FXa converts prothrombin to thrombin in the presence of factor Va, Ca2+, and phospholipid during blood clotting and cleaves prothrombin in two places (an arg-thr and then an arg-ile bond). This process is optimized when factor Xa is complexed with activated cofactor V in the prothrombinase complex. Inborn deficiency of factor X is very uncommon, and may present with epistaxis (nose bleeds), hemarthrosis (bleeding into joints) and gastrointestinal blood loss. Apart from congenital deficiency, low factor X levels may occur occasionally in a number of disease states. Furthermore, factor X deficiency may be seen in amyloidosis, where factor X is adsorbed to the amyloid fibrils in the vasculature. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human Coagulation Factor X / F10 protein (TMPY-01101) |
| Antigen Species | Human |
| Biology Area | Serine Proteases and Regulators |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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