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BI 99179

Name: BI 99179
Brand: TargetMol
SKU: T14570
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14570Cas No. 1291779-76-4

Alias BI99179

BI 99179 is a selective and potent inhibitor of type I fatty acid synthase (FAS), a tool compound for targeting FAS for cancer research.

BI 99179

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Purity: 98.73%

Catalog No. T14570Alias BI99179Cas No. 1291779-76-4

BI 99179 is a selective and potent inhibitor of type I fatty acid synthase (FAS), a tool compound for targeting FAS for cancer research.

Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$72	In Stock
10 mg	$108	In Stock
1 mL x 10 mM (in DMSO)	$82	In Stock

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Purity:98.73%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	BI 99179 is a selective and potent inhibitor of type I fatty acid synthase (FAS), a tool compound for targeting FAS for cancer research.
Targets&IC50	Fas:79 nM, N42 cells:0.6 μM
In vitro	BI 99179 demonstrated significant efficacy in mouse hypothalamic N-42 cells with an IC50 of 0.6 μM and no significant LDH release below 30 μM in cytotoxicity assays. [1] BI 99179 showed antiproliferative effects in human glioma GAMG cells at concentrations of 1, 2 and 4 μM. [2]
In vivo	Pharmacokinetically, BI 99179 also performed very well in male Han/Wistar rats, with a half-life (t1/2) of 3.0 hours at an oral dose of 4 mg/kg. [1]
Synonyms	BI99179

Chemical Properties

Molecular Weight	391.46
Formula	C₂₃H₂₅N₃O₃
Cas No.	1291779-76-4
Smiles	N(C(=O)[C@H]1C[C@@H](NC(CC)=O)CC1)(C)C2=CC=C(C3=NC=4C(O3)=CC=CC4)C=C2
Relative Density.	1.25 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (255.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5545 mL	12.7727 mL	25.5454 mL	127.7270 mL
5 mM	0.5109 mL	2.5545 mL	5.1091 mL	25.5454 mL
10 mM	0.2555 mL	1.2773 mL	2.5545 mL	12.7727 mL
20 mM	0.1277 mL	0.6386 mL	1.2773 mL	6.3863 mL
50 mM	0.0511 mL	0.2555 mL	0.5109 mL	2.5545 mL
100 mM	0.0255 mL	0.1277 mL	0.2555 mL	1.2773 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc