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BI 99179

Name: BI 99179
Brand: TargetMol
SKU: T14570
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14570Cas No. 1291779-76-4

Alias BI99179

BI 99179 is a selective and potent inhibitor of type I fatty acid synthase (FAS), a tool compound for targeting FAS for cancer research.

BI 99179

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Purity: 98.73%

Catalog No. T14570Alias BI99179Cas No. 1291779-76-4

BI 99179 is a selective and potent inhibitor of type I fatty acid synthase (FAS), a tool compound for targeting FAS for cancer research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	-	In Stock
5 mg	$72	-	In Stock
10 mg	$108	-	In Stock
1 mL x 10 mM (in DMSO)	$82	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.73%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	BI 99179 is a selective and potent inhibitor of type I fatty acid synthase (FAS), a tool compound for targeting FAS for cancer research.
Targets&IC50	N42 cells:0.6 μM, Fas:79 nM
In vitro	BI 99179 demonstrated significant efficacy in mouse hypothalamic N-42 cells with an IC50 of 0.6 μM and no significant LDH release below 30 μM in cytotoxicity assays. [1] BI 99179 showed antiproliferative effects in human glioma GAMG cells at concentrations of 1, 2 and 4 μM. [2]
In vivo	Pharmacokinetically, BI 99179 also performed very well in male Han/Wistar rats, with a half-life (t1/2) of 3.0 hours at an oral dose of 4 mg/kg. [1]
Synonyms	BI99179

Chemical Properties

Molecular Weight	391.46
Formula	C₂₃H₂₅N₃O₃
Cas No.	1291779-76-4
Smiles	N(C(=O)[C@H]1C[C@@H](NC(CC)=O)CC1)(C)C2=CC=C(C3=NC=4C(O3)=CC=CC4)C=C2
Relative Density.	1.25 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (255.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5545 mL	12.7727 mL	25.5454 mL	127.7270 mL
5 mM	0.5109 mL	2.5545 mL	5.1091 mL	25.5454 mL
10 mM	0.2555 mL	1.2773 mL	2.5545 mL	12.7727 mL
20 mM	0.1277 mL	0.6386 mL	1.2773 mL	6.3863 mL
50 mM	0.0511 mL	0.2555 mL	0.5109 mL	2.5545 mL
100 mM	0.0255 mL	0.1277 mL	0.2555 mL	1.2773 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc