Shopping Cart

Your shopping cart is currently empty

WAY-100635

Name: WAY-100635
Brand: TargetMol
SKU: T21561
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T21561Cas No. 162760-96-5

Alias WAY100635

WAY-100635 is a potent 5-HT 1A receptor antagonist with an IC50 = 0.91 nM that abrogates the reduction in hippocampal CA1 pyramidal neuron firing frequency during conditioned reflexes; it also acts as a dopamine D4 receptor agonist with an affinity of 3.3 nM.

WAY-100635

Copy Product Info

😃Good

Purity: 98.97%

Catalog No. T21561Alias WAY100635Cas No. 162760-96-5

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$36	-	In Stock
5 mg	$57	-	In Stock
10 mg	$97	-	In Stock
25 mg	$183	-	In Stock
50 mg	$272	-	In Stock
100 mg	$393	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$63	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.97%

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	WAY-100635 is a potent 5-HT 1A receptor antagonist with an IC50 = 0.91 nM that abrogates the reduction in hippocampal CA1 pyramidal neuron firing frequency during conditioned reflexes; it also acts as a dopamine D4 receptor agonist with an affinity of 3.3 nM.
Targets&IC50	5-HT1A receptor:8.87 (pIC50), 5-HT1A receptor:9.71 (pA2)
In vitro	The functional properties and binding affinities of WAY-100635 are evaluated in HEK 293 cells stably expressing dopamine D 2L or D 4.4 receptors [1]. WAY-100635 has binding affinities of 940, 370, and 16 nM on D 2L, D 3, and D 4.2 receptors, respectively. Saturation analyses shows that the K d of [ 3 H] WAY-100635 at D 4.2 receptors is 2.4 nM. WAY-100635 is potent agonist in HEK-D 4.4 cells with EC 50 of 9.7 nM. WAY-100635 possesses high affinity for D 4.4 receptor (3.3 nM) [1].
In vivo	Treatment with WAY-100635 (1 mg/kg; subcutaneous injection; male Sprague-Dawley rats) abolishes the reduction of the severity of abstinence signs induced by Rhodiola rosea administration in nicotine-dependent rat [2]. Animal Model: Male Sprague-Dawley rats (220-240 g) [2] Dosage: 1 mg/kg Administration: Subcutaneous injection (Pharmacokinetic study) Result: Reduced total abstinence score, increased immobility time and the burying behavior was increased.
Synonyms	WAY100635

Chemical Properties

Molecular Weight	422.56
Formula	C₂₅H₃₄N₄O₂
Cas No.	162760-96-5
Smiles	O=C(N(C1=NC=CC=C1)CCN2CCN(C=3C=CC=CC3OC)CC2)C4CCCCC4
Relative Density.	1.154 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (118.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3665 mL	11.8326 mL	23.6653 mL	118.3264 mL
5 mM	0.4733 mL	2.3665 mL	4.7331 mL	23.6653 mL
10 mM	0.2367 mL	1.1833 mL	2.3665 mL	11.8326 mL
20 mM	0.1183 mL	0.5916 mL	1.1833 mL	5.9163 mL
50 mM	0.0473 mL	0.2367 mL	0.4733 mL	2.3665 mL
100 mM	0.0237 mL	0.1183 mL	0.2367 mL	1.1833 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc