Powder: -20°C for 3 years | In solvent: -80°C for 1 year
WAY-100635 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 of 0.91 nM and Ki of 0.39 nM. It exhibits pIC50 values of 8.9 and 6.6 for 5-HT1A and α1-adrenergic receptors, respectively. Moreover, WAY-100635 acts as a potent agonist of the dopamine D4 receptor [1] [2] [3].
Pack Size | Availability | Price/USD | Quantity |
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2 mg | 5 days | $ 73.00 |
Description | WAY-100635 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 of 0.91 nM and Ki of 0.39 nM. It exhibits pIC50 values of 8.9 and 6.6 for 5-HT1A and α1-adrenergic receptors, respectively. Moreover, WAY-100635 acts as a potent agonist of the dopamine D4 receptor [1] [2] [3]. |
In vitro | The functional properties and binding affinities of WAY-100635 were assessed in HEK 293 cells that stably express dopamine D 2L or D 4.4 receptors [1]. The compound exhibits binding affinities of 940, 370, and 16 nM for D 2L, D 3, and D 4.2 receptors, respectively. Saturation analysis revealed that the dissociation constant (Kd) of [3 H]WAY-100635 at D 4.2 receptors is 2.4 nM. Furthermore, WAY-100635 acts as a potent agonist in HEK-D 4.4 cells, demonstrating an effective concentration 50 (EC50) of 9.7 nM and shows high affinity for the D 4.4 receptor at 3.3 nM [1]. |
In vivo | Administration of WAY-100635 (1 mg/kg; subcutaneous injection) to male Sprague-Dawley rats counteracts the decrease in severity of withdrawal symptoms observed following Rhodiola rosea treatment in nicotine-dependent rats [2]. This pharmacokinetic study utilized an animal model consisting of male Sprague-Dawley rats weighing 220-240 g, treated with a dosage of 1 mg/kg via subcutaneous injection. The outcomes included a reduction in total withdrawal scores, alongside an increase in immobility time and burying behavior. |
Molecular Weight | 422.56 |
Formula | C25H34N4O2 |
CAS No. | 162760-96-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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WAY-100635 162760-96-5 WAY100635 WAY 100635 inhibitor inhibit