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NH2-PEG3-C1-Boc

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Catalog No. T16666Cas No. 189808-70-6

NH2-PEG3-C1-Boc is a PEG-based PROTAC linker that can be used for the synthesis of PROTAC molecules.

NH2-PEG3-C1-Boc

NH2-PEG3-C1-Boc

😃Good
Catalog No. T16666Cas No. 189808-70-6
NH2-PEG3-C1-Boc is a PEG-based PROTAC linker that can be used for the synthesis of PROTAC molecules.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$32-In Stock
50 mg$45-In Stock
100 mg$64-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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COA HNMR MS

Product Introduction

Bioactivity
Description
NH2-PEG3-C1-Boc is a PEG-based PROTAC linker that can be used for the synthesis of PROTAC molecules.
In vitro
PROTACs comprise two ligands linked together: one targets an E3 ubiquitin ligase, and the other binds the target protein. They harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].
Chemical Properties
Molecular Weight263.33
FormulaC12H25NO5
Cas No.189808-70-6
SmilesO=C(OC(C)(C)C)COCCOCCOCCN
Relative Density.1.041 g/cm3 (Predicted)
ColorTransparent
AppearanceOil
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (303.8 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.7975 mL18.9876 mL37.9752 mL189.8758 mL
5 mM0.7595 mL3.7975 mL7.5950 mL37.9752 mL
10 mM0.3798 mL1.8988 mL3.7975 mL18.9876 mL
20 mM0.1899 mL0.9494 mL1.8988 mL9.4938 mL
50 mM0.0760 mL0.3798 mL0.7595 mL3.7975 mL
100 mM0.0380 mL0.1899 mL0.3798 mL1.8988 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PROTAC Linker 5PEGsNH2-PEG3-C1-BocNH-2-PEG3-C1-BocNH2PEG3C1BocNH2 PEG3 C1 Boc
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