Venadaparib hydrochloride

Name: Venadaparib hydrochloride
Brand: TargetMol
SKU: T39147
Rating: 4.5 (1 reviews)

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Catalog No. T39147Cas No. 1681020-60-9

Alias IDX-1197 hydrochloride

Venadaparib hydrochloride (IDX-1197) is a potent and selective PARP inhibitor exhibiting significant anticancer properties, particularly effective in solid tumor research.

Venadaparib hydrochloride

😃Good

Catalog No. T39147Alias IDX-1197 hydrochlorideCas No. 1681020-60-9

Venadaparib hydrochloride (IDX-1197) is a potent and selective PARP inhibitor exhibiting significant anticancer properties, particularly effective in solid tumor research.

Pack Size	Price	Availability	Quantity
5 mg	$970	1-2 weeks

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Bioactivity

Description	Venadaparib hydrochloride (IDX-1197) is a potent and selective PARP inhibitor exhibiting significant anticancer properties, particularly effective in solid tumor research.
Targets&IC50	PARP2:1 nM (IC50), PARP1:1.4 nM (IC50)
In vitro	Venadaparib (example 143; 6-10 days) effectively inhibits the growth of MDA-MB-436 and Capan-1 pancreatic cancer cells, with IC50 values of ≤5nM and 50nM[2], respectively.
In vivo	In the germline BRCA1-mutated ovarian cancer patient-derived xenograft (PDX) model, oral administration of Venadaparib (IDX-1197) significantly inhibits PAR (>90%) in tumor tissues for up to 24 hours post-dosing and exhibits dose-dependent, potent tumor growth inhibition, surpassing that of the Olaparib treatment group[1].
Synonyms	IDX-1197 hydrochloride

Chemical Properties

Molecular Weight	442.92
Formula	C₂₃H₂₄ClFN₄O₂
Cas No.	1681020-60-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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