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Caffeic Acid

Name: Caffeic Acid
Brand: TargetMol
SKU: T2807
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2807Cas No. 331-39-5

Caffeic acid is a dual inhibitor of 5-lipoxygenase and TRPV1 ion channels.

Caffeic Acid

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Purity: 99.3%

Catalog No. T2807Cas No. 331-39-5

Caffeic acid is a dual inhibitor of 5-lipoxygenase and TRPV1 ion channels.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.3%

Color:Yellow

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COA HNMR HPLC

Product Introduction

Caffeic Acid AI Summary

Caffeic Acid demonstrates multiple bioactivities. As an inhibitor of EGF-dependent autophosphorylation of epidermal growth factor receptor kinase, it shows an IC50 value of 1,200,000 nM and a Ki value of 400,000 nM. It exhibits in vitro antimalarial activity against Plasmodium falciparum with an IC50 value of 122,000 nM. The compound also shows significant antioxidant properties, including DPPH radical scavenging with an IC50 value of 57,000 nM, ABTS with an IC50 of 257,000 nM, and superoxide anion scavenging activity with an IC50 of 2900 nM. Additionally, it demonstrates hydroxyl radical scavenging activity with an IC50 value of 500 nM and antioxidant bioactivities through inhibition of lipid peroxidation. The compound inhibits various lipoxygenases (IC50 values: potato 5-LOX - 4000 nM, soybean 15-LOX - 600,000 nM) and other enzymes such as beta-glucuronidase and human carbonic anhydrase. It also exhibits anti-inflammatory and antiviral activities, including inhibition of HIV-1 integrase and protease. Although it shows inhibition and moderate cytotoxicity in various assays, it presents potential therapeutic properties across a wide range of bioactivities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Caffeic acid is a dual inhibitor of 5-lipoxygenase and TRPV1 ion channels.
Targets&IC50	renin:5704 µM, DNA methylation:3.0 μM, Canine distemper virus:23.3 μg/mL (at 1h post infection)
In vitro	METHODS: Human A549 cells were treated with Caffeic Acid for 48 h, and cell growth inhibition was measured using MTT assay. RESULTS: Caffeic Acid inhibited the growth of A549 cells (IC50=0.7 mM). [1] METHODS: Human AGS and HCT-116 cells were treated with Caffeic Acid for 96 hours, and cell growth inhibition was detected using MTT assay. RESULTS: Caffeic Acid inhibited the growth of AGS (IC50=129 μM) and HCT-116 (IC50=29.73 μM) cells. [2]
In vivo	METHODS: To study the anti-pruritus effect of Caffeic Acid, Caffeic Acid (500 mg/kg) was orally administered to mice induced by histamine and chloroquine. RESULTS: Caffeic acid pretreated mice showed significantly less histamine-induced scratching and chloroquine-induced scratching. [3]

Chemical Properties

Molecular Weight	180.16
Formula	C₉H₈O₄
Cas No.	331-39-5
Smiles	C(=CC(O)=O)C1=CC(O)=C(O)C=C1
Relative Density.	1.2933 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 250 mg/mL (1387.66 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (27.75 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5506 mL	27.7531 mL	55.5062 mL	277.5311 mL
5 mM	1.1101 mL	5.5506 mL	11.1012 mL	55.5062 mL
10 mM	0.5551 mL	2.7753 mL	5.5506 mL	27.7531 mL
20 mM	0.2775 mL	1.3877 mL	2.7753 mL	13.8766 mL
50 mM	0.1110 mL	0.5551 mL	1.1101 mL	5.5506 mL
100 mM	0.0555 mL	0.2775 mL	0.5551 mL	2.7753 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc