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Caffeic Acid

Name: Caffeic Acid
Brand: TargetMol
SKU: T2807
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2807Cas No. 331-39-5

Caffeic acid is a dual inhibitor of 5-lipoxygenase and TRPV1 ion channels.

Caffeic Acid

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Purity: 99.3%

Catalog No. T2807Cas No. 331-39-5

Caffeic acid is a dual inhibitor of 5-lipoxygenase and TRPV1 ion channels.

Pack Size	Price	Availability	Quantity
100 mg	$29	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:99.3%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Caffeic acid is a dual inhibitor of 5-lipoxygenase and TRPV1 ion channels.
Targets&IC50	Canine distemper virus:23.3 μg/mL (at 1h post infection), DNA methylation:3.0 μM, renin:5704 µM
In vitro	METHODS: Human A549 cells were treated with Caffeic Acid for 48 h, and cell growth inhibition was measured using MTT assay. RESULTS: Caffeic Acid inhibited the growth of A549 cells (IC50=0.7 mM). [1] METHODS: Human AGS and HCT-116 cells were treated with Caffeic Acid for 96 hours, and cell growth inhibition was detected using MTT assay. RESULTS: Caffeic Acid inhibited the growth of AGS (IC50=129 μM) and HCT-116 (IC50=29.73 μM) cells. [2]
In vivo	METHODS: To study the anti-pruritus effect of Caffeic Acid, Caffeic Acid (500 mg/kg) was orally administered to mice induced by histamine and chloroquine. RESULTS: Caffeic acid pretreated mice showed significantly less histamine-induced scratching and chloroquine-induced scratching. [3]

Chemical Properties

Molecular Weight	180.16
Formula	C₉H₈O₄
Cas No.	331-39-5
Smiles	C(=CC(O)=O)C1=CC(O)=C(O)C=C1
Relative Density.	1.2933 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 250 mg/mL (1387.66 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5506 mL	27.7531 mL	55.5062 mL	277.5311 mL
5 mM	1.1101 mL	5.5506 mL	11.1012 mL	55.5062 mL
10 mM	0.5551 mL	2.7753 mL	5.5506 mL	27.7531 mL
20 mM	0.2775 mL	1.3877 mL	2.7753 mL	13.8766 mL
50 mM	0.1110 mL	0.5551 mL	1.1101 mL	5.5506 mL
100 mM	0.0555 mL	0.2775 mL	0.5551 mL	2.7753 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc