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FAUC 213
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Catalog No. T24055Cas No. 337972-47-1
Alias FAUC-213, FAUC213
FAUC 213 is a selective full antagonist of the dopamine D4 receptor.
FAUC 213
Copy Product Info🥰Excellent
Purity: 99.84%
Catalog No. T24055Alias FAUC-213, FAUC213Cas No. 337972-47-1
FAUC 213 is a selective full antagonist of the dopamine D4 receptor.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $33 | In Stock | In Stock | |
| 5 mg | $56 | In Stock | In Stock | |
| 10 mg | $89 | In Stock | In Stock | |
| 25 mg | $179 | In Stock | In Stock | |
| 50 mg | Preferential | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.84%
Appearance:Solid
Color:White
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Product Introduction
FAUC 213 AI Summary
FAUC 213 exhibits a diverse pharmacological profile with high selectivity and binding affinity for several human dopamine receptors, particularly the D4 receptor. It binds with a Ki value of 2.2 nM to the human dopamine D4.4 receptor, indicating very strong affinity. Additionally, it displays moderate affinities to dopamine receptors D1 (Ki = 5500.0 nM), D2L (Ki = 3400.0 nM), D2S (Ki = 6300.0 nM), and D3 (Ki = 5300.0 nM). The compound shows partial agonistic activity at the D4 receptor with less than 3.0% mitogenic activity as indicated by [3H]thymidine incorporation.
Furthermore, FAUC 213 demonstrates intrinsic activity in a calcium flux assay for the D4 receptor with 19.0% efficacy in the presence of co-transfected G-alpha-qo5 protein, and a substantial selectivity ratio of 489.0 for D4 over D2 receptors. Apart from dopamine receptors, the compound also interacts with other neurotransmitter receptors, including 5HT1A, 5HT2, and adrenergic alpha-1 receptors, suggesting possible broader implications for receptor modulation. Overall, the compound’s high affinity for Dopamine D4 and varied receptor activities highlight its potential therapeutic utility for conditions involving dopamine dysregulation..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | FAUC 213 is a selective full antagonist of the dopamine D4 receptor. |
| Targets&IC50 | D2 receptor (human):3.4 μM (Ki), D4.4 receptor (human):2.2 nM (Ki), D3 receptor (human):5.3 μM (Ki) |
| Synonyms | FAUC-213, FAUC213 |
| Molecular Weight | 326.82 |
| Formula | C18H19ClN4 |
| Cas No. | 337972-47-1 |
| Smiles | Clc1ccc(cc1)N1CCN(Cc2cc3ccccn3n2)CC1 |
| Relative Density. | 1.28g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.27 mg/mL (10.01 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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