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CP681301

Name: CP681301
Brand: TargetMol
SKU: T60661
Rating: 4.5 (1 reviews)

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CP681301 is a highly potent and specific small molecule inhibitor of CDK5 with an inhibition constant (Ki) of 13.7 nM for CDK5. CP681301 not only completely blocks the kinase activity of CDK5-p35 and CDK5-p25 complexes but also effectively inhibits the expression of stem cell markers (such as SOX2, OLIG2) and the self-renewal capacity of tumor cells in glioma stem cell models, demonstrating anti-tumor proliferative activity.

Cas No. 865317-32-4

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Pack Size	Price	USA Stock	Global Stock
2 mg	$72	6-8 weeks	6-8 weeks
5 mg	$123	6-8 weeks	6-8 weeks
10 mg	$197	6-8 weeks	6-8 weeks
25 mg	$367	6-8 weeks	6-8 weeks
50 mg	$548	6-8 weeks	6-8 weeks
100 mg	$828	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$135	6-8 weeks	6-8 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	CP681301 is a highly potent and specific small molecule inhibitor of CDK5 with an inhibition constant (Ki) of 13.7 nM for CDK5. CP681301 not only completely blocks the kinase activity of CDK5-p35 and CDK5-p25 complexes but also effectively inhibits the expression of stem cell markers (such as SOX2, OLIG2) and the self-renewal capacity of tumor cells in glioma stem cell models, demonstrating anti-tumor proliferative activity.
In vitro	CP681301 (1 µM; 96 h) shows variably cytotoxic to the tested GSC cultures but is not toxic to NHNPs[1]. CP681301 (0, 10, 50 µM; 48 h) decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in GSCs[1]. CP681301 (0, 0.5, 1 µM; ) suppresses the expression of CREB Ser133 phosphorylation[1].
In vivo	CP681301 (1 mM; fed; 10 days) shows anti-tumor activity in 0- to 2-day-old adult Drosophila[1].

Chemical Properties

Molecular Weight	298.38
Formula	C₁₇H₂₂N₄O
Cas No.	865317-32-4
Smiles	O=C(NC1=NNC(=C1)C2CCC2)CC3=CC=C(C=C3)N(C)C

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (268.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3514 mL	16.7572 mL	33.5143 mL	167.5716 mL
5 mM	0.6703 mL	3.3514 mL	6.7029 mL	33.5143 mL
10 mM	0.3351 mL	1.6757 mL	3.3514 mL	16.7572 mL
20 mM	0.1676 mL	0.8379 mL	1.6757 mL	8.3786 mL
50 mM	0.0670 mL	0.3351 mL	0.6703 mL	3.3514 mL
100 mM	0.0335 mL	0.1676 mL	0.3351 mL	1.6757 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: CP681301 chemical structure | CP681301 in vivo | CP681301 in vitro | CP681301 formula | CP681301 molecular weight