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BM-PEG3

Name: BM-PEG3
Brand: TargetMol
SKU: T17637
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17637Cas No. 86099-06-1

Alias 1,11-Bis-maleimidotetraethyleneglycol

BM-PEG3 (1,11-Bis-maleimidotetraethyleneglycol) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

BM-PEG3

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Purity: 99.87%

Catalog No. T17637Alias 1,11-Bis-maleimidotetraethyleneglycolCas No. 86099-06-1

BM-PEG3 (1,11-Bis-maleimidotetraethyleneglycol) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$29	In Stock	In Stock
50 mg	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.87%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	BM-PEG3 (1,11-Bis-maleimidotetraethyleneglycol) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
In vitro	PROTACs, composed of two distinct ligands joined by a linker—one binding to an E3 ubiquitin ligase and the other to the target protein—use the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Synonyms	1,11-Bis-maleimidotetraethyleneglycol

Chemical Properties

Molecular Weight	352.34
Formula	C₁₆H₂₀N₂O₇
Cas No.	86099-06-1
Smiles	C(COCCOCCOCCN1C(=O)C=CC1=O)N2C(=O)C=CC2=O
Relative Density.	1.335 g/cm3 (Predicted)
Color	White
Appearance	solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 1 mg/mL (2.84 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8382 mL	14.1908 mL	28.3817 mL	141.9084 mL
5 mM	0.5676 mL	2.8382 mL	5.6763 mL	28.3817 mL
10 mM	0.2838 mL	1.4191 mL	2.8382 mL	14.1908 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc