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Anti-RIPK3 Polyclonal Antibody
(Synonyms: RIP-like protein kinase 3, RIPK3, RIP3, Receptor-interacting serine/threonine-protein kinase 3, Receptor-interacting protein 3 (RIP-3)) Copy Product Info
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Synonyms: RIP-like protein kinase 3, RIPK3, RIP3, Receptor-interacting serine/threonine-protein kinase 3, Receptor-interacting protein 3 (RIP-3)
Catalog No. TMAB-01622 Copy Product Info
🥰Excellent
Anti-RIPK3 Polyclonal Antibody is a Rabbit antibody targeting RIPK3. Anti-RIPK3 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
Anti-RIPK3 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-RIPK3 Polyclonal Antibody is a Rabbit antibody targeting RIPK3. Anti-RIPK3 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB. |
| Synonyms | RIP-like protein kinase 3, RIPK3, RIP3, Receptor-interacting serine/threonine-protein kinase 3, Receptor-interacting protein 3 (RIP-3) |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Dog,Pig,Cow,Rabbit,GuineaPig) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Cell membrane. Mitochondrion (Potential). |
| Tissue Specificity | Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008] |
| Immunogen | KLH conjugated synthetic peptide: human RIPK3 |
| Antigen Species | Human |
| Gene Name | RIPK3 |
| Gene ID | |
| Protein Name | Receptor-interacting serine/threonine-protein kinase 3 |
| Uniprot ID | |
| Biology Area | Associated Proteins,Necroptosis,Kinases,Associated Proteins,TLR Signaling,Other Kinases |
| Function | Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. |
| Molecular Weight | Theoretical: 57 kDa. Actual: 60 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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