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Flurofamide

Name: Flurofamide
Brand: TargetMol
SKU: T11305
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11305Cas No. 70788-28-2

Flurofamide is an effective bacterial urease inhibitor and has potential in the treatment of infected urinary calculi.

Flurofamide

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Purity: 98.00%

Catalog No. T11305Cas No. 70788-28-2

Flurofamide is an effective bacterial urease inhibitor and has potential in the treatment of infected urinary calculi.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$44	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.00%

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COA HNMR LCMS

Product Introduction

Flurofamide AI Summary

Flurofamide exhibits diverse bioactivities across multiple targets and pathogens. It significantly inhibits urease activity in H. pylori strain CCUG 15818 in a concentration-dependent manner, reducing activity by 80.0%, 10.0%, and 0.0% at concentrations of 1 nM, 10 nM, and 100 nM, respectively. Additionally, it shows potent activity in a qHTS assay for Anthrax Lethal Toxin Internalization with an IC50 of 316.2 nM, and inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) with a potency of 105.9 nM (absence of CPT) and 3.3 nM (presence of CPT). Furthermore, Flurofamide demonstrates moderate effectiveness in blocking Ebola virus entry, with AC50 values of 8912.5 nM in the green channel, 8.913 µM in the blue channel, and 44.67 µM in the ratio channel. In terms of antiviral activities, Flurofamide inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells with inhibition rates of -8.48% and 0.09% at 10 µM after 48 hours, respectively. It also shows potential inhibition of the SARS-CoV-2 3CL-Pro protease with 17.65% activity at 20µM. Moreover, Flurofamide exhibits enzymatic inhibition on human HDAC6 with inhibition rates of 12.59% using a commercial peptide substrate and -13.41% with a custom peptide substrate. These findings indicate Flurofamide’s broad-spectrum bioactivity, making it a promising candidate for further pharmacological studies..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Flurofamide is an effective bacterial urease inhibitor and has potential in the treatment of infected urinary calculi.

Chemical Properties

Molecular Weight	217.14
Formula	C₇H₉FN₃O₂P
Cas No.	70788-28-2
Smiles	C(NP(N)(N)=O)(=O)C1=CC=C(F)C=C1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (138.16 mM), Sonication and heating to 60℃ are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (4.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6053 mL	23.0266 mL	46.0532 mL	230.2662 mL
5 mM	0.9211 mL	4.6053 mL	9.2106 mL	46.0532 mL
10 mM	0.4605 mL	2.3027 mL	4.6053 mL	23.0266 mL
20 mM	0.2303 mL	1.1513 mL	2.3027 mL	11.5133 mL
50 mM	0.0921 mL	0.4605 mL	0.9211 mL	4.6053 mL
100 mM	0.0461 mL	0.2303 mL	0.4605 mL	2.3027 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc