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Anti-ALAS2 Antibody (2M567) is a Mouse antibody targeting ALAS2. Anti-ALAS2 Antibody (2M567) can be used in WB,IP,IF,IHC-P.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $298 | 7-10 days | |
100 μL | $426 | 7-10 days |
Description | Anti-ALAS2 Antibody (2M567) is a Mouse antibody targeting ALAS2. Anti-ALAS2 Antibody (2M567) can be used in WB,IP,IF,IHC-P. |
Alias | XLSA, XLEPP, XLDPP, SIDBA1, RP23-338A17.1, OTTMUSP00000020679, OTTHUMP00000023389, OTTHUMP00000023388, mitochondrial, HEM0_HUMAN, FLJ93603, erythroid-specific, Erythroid specific ALAS, Delta-aminolevulinate synthase 2, Delta-ALA synthase 2, Delta aminolevulinate synthase 2, Delta aminolevulinate synthase, Delta ALA synthetase, Delta ALA synthase 2, ASB, ANH1, Aminolevulinic acid synthase 2, erythroid, Aminolevulinate delta synthase 2, ALAS-E, ALASE, Alas2, ALAS, erythroid, ALAS E, Alas 2, ALAS, 5-aminolevulinic acid synthase 2, 5-aminolevulinate synthase, 5 aminolevulinic acid synthase 2, 5 aminolevulinic acid synthase, 5 aminolevulinate synthase erythroid specific mitochondrial, 5 aminolevulinate synthase 5 aminolevulinate synthase 2, 5 aminolevulinate synthase 2, 5 @aminolevulinate synthase erythroid specific |
Reactivity | Human,Mouse,Rat |
Application | |
Recommended Dose | WB: 1:100-1000; IHC-P: 1:50-500; IP: 1-2 μg per 100-500 μg of total protein (1 ml of cell lysate) |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | Hybridoma Monoclonal Antibody |
Purification | ProA affinity purified |
Appearance | Liquid |
Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
Research Background | 5-aminolevulinate synthase 1 (ALAS-H) and 2 (ALAS-E) are two isoforms of ALAS, an enzyme catalyzing the first step of the heme biosynthetic pathway in mammals. The erythroid-specific isoenzyme, ALAS-E, regulates the first step of hematopoietic cell differentation and iron metabolism in the liver. ALAS-H is a housekeeping protein which mediates synthesis of early heme in the mitochondria of most cells. Succinyl CoA associates with ALAS-E in protein conformation change and translocation of ALAS-E into the mitochondria and does not interact with ALAS-H. The ALAS-E 5'-flanking region contains binding sites for nuclear activators such as GATA-1, NF-E2 and EKLF. Since the ALAS gene maps to the X chromosome, mutation of the gene leads to the pyridoxine-refractory X-linked sideroblastic anemia. |
Conjucates | Unconjugated |
Immunogen | Peptide |
Uniprot ID |
Molecular Weight | Theoretical: 60 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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