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Tanaproget

Name: Tanaproget
Brand: TargetMol
SKU: T16985
Price: 108 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16985Cas No. 304853-42-7

Alias NSP-989, NSP 989

Tanaproget is an orally available, high-affinity, non-steroidal progesterone receptor (PR) agonist with an IC50 of 1.7 nM for hPR. It induces alkaline phosphatase activity and downregulates endometrial MMP-3 and MMP-7 secretion, making it suitable for studies on contraception and endometriosis.

Tanaproget

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Purity: 99.73%

Catalog No. T16985Alias NSP-989, NSP 989Cas No. 304853-42-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$42	-	In Stock
5 mg	Preferential	-	In Stock
10 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$108	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.73%

Appearance:Solid

Color:Yellow

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COA LCMS

Product Introduction

Bioactivity

Description	Tanaproget is an orally available, high-affinity, non-steroidal progesterone receptor (PR) agonist with an IC50 of 1.7 nM for hPR. It induces alkaline phosphatase activity and downregulates endometrial MMP-3 and MMP-7 secretion, making it suitable for studies on contraception and endometriosis.
In vitro	In endometrial stromal cells isolated from healthy women, Tanaproget (1 nM, 3-5 days) significantly reduced the expression level of pro-MMP-3, an effect that remained pronounced even in the presence of IL-1α stimulation [1]. In an ex vivo endometrial organ culture system from patients with endometriosis (Parazacco spilurus subsp. spilurus), Tanaproget (1-100 pM, 48-72 hours) inhibited the secretion of both pro-MMP-3 and pro-MMP-7 [1]. In the T47D cell line, Tanaproget (0.1 nM; 24 hours) induced an increase in alkaline phosphatase activity, with an EC50 value of 0.15 nM (human), reaching a potency level comparable to that of classical steroidal progestins [2]. Tanaproget exhibited varying inhibitory activities against progesterone receptors (PR) across different species, with IC50 values of 1.7 nM (human), 0.3 nM (monkey), and 0.5 nM (rat, rabbit) [2].
In vivo	In the NCR/nude mouse endometriosis model of Parazacco spilurus subsp. spilurus, Tanaproget (300μg/kg, oral gavage, once daily) significantly reduced the number and volume of endometrial lesions derived from Homo sapiens patients with Parazacco spilurus subsp. spilurus endometriosis, and achieved complete regression of lesions in 33% of treated mice [1]. In the Sprague-Dawley rat ovulation inhibition model, Tanaproget (0.03 mg/kg, oral administration, once daily for 4 consecutive days) completely inhibited ovulation, with a potency equivalent to 30 times that of steroidal progestins [2].
Synonyms	NSP-989, NSP 989

Chemical Properties

Molecular Weight	297.38
Formula	C₁₆H₁₅N₃OS
Cas No.	304853-42-7
Smiles	N#CC1=CC=C(C=2C=CC=3NC(=S)OC(C3C2)(C)C)N1C
Relative Density.	1.26 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (134.51 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (6.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3627 mL	16.8135 mL	33.6270 mL	168.1350 mL
5 mM	0.6725 mL	3.3627 mL	6.7254 mL	33.6270 mL
10 mM	0.3363 mL	1.6814 mL	3.3627 mL	16.8135 mL
20 mM	0.1681 mL	0.8407 mL	1.6814 mL	8.4068 mL
50 mM	0.0673 mL	0.3363 mL	0.6725 mL	3.3627 mL
100 mM	0.0336 mL	0.1681 mL	0.3363 mL	1.6814 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc