ST2/IL-1 RL1 Protein, Mouse, Recombinant (His)

Name: ST2/IL-1 RL1 Protein, Mouse, Recombinant (His)
Brand: TargetMol
SKU: TMPY-04096
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: T1/ST2, T1, St2-rs1, ST2L, St2, Ly84, interleukin 1 receptor-like 1, Fit-1, DER4) Copy Product Info

Synonyms: T1/ST2, T1, St2-rs1, ST2L, St2, Ly84, interleukin 1 receptor-like 1, Fit-1, DER4

Catalog No. TMPY-04096 Copy Product Info

Purity: 98.2%

ST2/IL-1 RL1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is P14719-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$48	-	In Stock
10 µg	$75	-	In Stock
20 µg	$118	-	In Stock
50 µg	$229	-	In Stock
100 µg	$386	-	In Stock
200 µg	$682	7-10 days	7-10 days
500 µg	$1,430	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.2%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Information

Bioactivity

Bioactivity	Immobilized Mouse ST2/IL-1 RL1 Protein (His) (TMPY-04096) at 2 μg/mL (100 μL/well) can bind Anti-Mouse ST2 Antibody (T9901A-641). The EC50 is 8.07 ng/mL.
Description	ST2/IL-1 RL1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is P14719-1.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-His
Accession Number	P14719-1
Construction	A DNA sequence encoding the mouse ST2 (NP_001020773.1) (Met1-Arg332) was expressed with a C-terminal polyhistidine tag. Predicted N terminal: Ser 27
Protein Purity	> 95 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	T1/ST2, T1, St2-rs1, ST2L, St2, Ly84, interleukin 1 receptor-like 1, Fit-1, DER4
Research Background	IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage proinflammatory function. IL33 is a specific ligand of ST2L and induces the production of Th2 cytokines.

Chemical Properties

Molecular Weight

36.5 kDa (predicted); 55.7 kDa (reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.