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Zilovertamab

(Synonyms: UC-961, Cirmtuzumab, 1643432-38-5) Copy Product Info
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Synonyms: UC-961, Cirmtuzumab, 1643432-38-5

Catalog No. T76749 Copy Product Info
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Zilovertamab (UC-961) is a humanized anti-ROR1 monoclonal antibody that cuts off the WNT5A-induced ROR1 signaling pathway and shows anti-proliferative activity in ovarian and endometrial cancer cells. It can be used to study lymphatic cancer.
Zilovertamab
Cas No. 2485779-13-1
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Pack SizePriceUSA StockGlobal StockQuantity
1 mg$247In StockIn Stock
5 mg$690In StockIn Stock
10 mg$1,120-In Stock
25 mg$1,660-In Stock
50 mg$2,230-In Stock
100 mg$2,950InquiryInquiry
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:98.3% (SDS-PAGE); 98.1% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction

Bioactivity
Description
Zilovertamab (UC-961) is a humanized anti-ROR1 monoclonal antibody that cuts off the WNT5A-induced ROR1 signaling pathway and shows anti-proliferative activity in ovarian and endometrial cancer cells. It can be used to study lymphatic cancer.
In vitro
Zilovertamab (25 and 50 µg/mL; 72 h) inhibits the proliferation of high-grade serous ovarian cancer (HGSOC) cells[1].
Zilovertamab (50 µg/mL; 72 h) down-regulates the expression levels of ROR1 in CaOV3 at the transcriptional level[1].
Expression System
CHO
Endotoxin<1.0 EU/mg
SynonymsUC-961, Cirmtuzumab, 1643432-38-5
Reactivity
Human
Verified Activity
Immobilized Human ROR1 Protein (His) (TMPY-04649) at 1 μg/mL (100 μL/well) can bind Zilovertamab. The EC50 is 2.13 ng/mL.
Zilovertamab
Application
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Gene ID
Uniprot ID
TargetROR1
Chemical Properties
Molecular Weight144.57 kDa
Cas No.2485779-13-1
Antibody Information
IsotypeHuman IgG1 kappa
Recommended Isotype Control
Storage & Solubility Information
StorageStore at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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Keywords

Related Tags: Zilovertamab chemical structure | Zilovertamab in vitro | Zilovertamab molecular weight