Shopping Cart

Your shopping cart is currently empty

TP-064

Name: TP-064
Brand: TargetMol
SKU: T28996
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T28996Cas No. 2080306-20-1

Alias TP 064

TP-064 is a potent and selective PRMT4 inhibitor, featuring an IC50 < 10nM for methylation of H3 (1-25) and over 100-fold selectivity compared to other histone methyltransferases and non-epigenetic targets. It inhibits the methylation of MED12 in cells with an IC50 of 43 nM.

TP-064

Copy Product Info

😃Good

Purity: 97.85%

Catalog No. T28996Alias TP 064Cas No. 2080306-20-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
2 mg	$45	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$257	In Stock	In Stock
50 mg	$513	In Stock	In Stock
100 mg	$748	-	In Stock
1 mL x 10 mM (in DMSO)	$73	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:97.85%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

TP-064 AI Summary

TP-064 exhibits varying effects on cell viability across different cell types, including U2OS, human fibroblast, and HEK293T, showing both increases and decreases in growth rates. Its bioactivity may involve modulation of cellular functions related to viability and proliferation. Thermal Shift Assay results indicate that TP-064 affects the thermal stability of various protein domains, with decreases in stability noted in domains N44-E168, M626-G740, and M26-R383, and increases in stability observed in domains S229-K512, M1-L298, M1-K294, P449-E759, M1-S360, and G861-E979. Additionally, TP-064 potently inhibits FLAG-tagged CARM1 with an IC50 value of less than 10.0 nM, likely by disrupting the enzymatic activity through interaction with the substrate or necessary cofactors. This suggests TP-064's role in modulating both cellular viability mechanisms and protein stability..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	TP-064 is a potent and selective PRMT4 inhibitor, featuring an IC50 < 10nM for methylation of H3 (1-25) and over 100-fold selectivity compared to other histone methyltransferases and non-epigenetic targets. It inhibits the methylation of MED12 in cells with an IC50 of 43 nM.
Targets&IC50	MED12:43 nM(IC50), BAF155:340 nM(IC50), PRMT6:1300 μM, PRMT4:<10 nM
Synonyms	TP 064

Chemical Properties

Molecular Weight	458.6
Formula	C₂₈H₃₄N₄O₂
Cas No.	2080306-20-1
Smiles	CNCCN1CCC(CC1)c1cc(CN(C)C(=O)c2cccc(Oc3ccccc3)c2)ccn1
Relative Density.	1.134 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (109.03 mM), Sonication and heating to 60℃ are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.72 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1805 mL	10.9027 mL	21.8055 mL	109.0275 mL
5 mM	0.4361 mL	2.1805 mL	4.3611 mL	21.8055 mL
10 mM	0.2181 mL	1.0903 mL	2.1805 mL	10.9027 mL
20 mM	0.1090 mL	0.5451 mL	1.0903 mL	5.4514 mL
50 mM	0.0436 mL	0.2181 mL	0.4361 mL	2.1805 mL
100 mM	0.0218 mL	0.1090 mL	0.2181 mL	1.0903 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc