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TP-064

Name: TP-064
Brand: TargetMol
SKU: T28996
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T28996Cas No. 2080306-20-1

Alias TP 064

TP-064 is a potent and selective PRMT4 inhibitor, featuring an IC50 < 10nM for methylation of H3 (1-25) and over 100-fold selectivity compared to other histone methyltransferases and non-epigenetic targets. It inhibits the methylation of MED12 in cells with an IC50 of 43 nM.

TP-064

🥰Excellent

Purity: 97.85%

Catalog No. T28996Alias TP 064Cas No. 2080306-20-1

Pack Size	Price	Availability
1 mg	$32	In Stock
2 mg	$45	In Stock
5 mg	$72	In Stock
10 mg	$122	In Stock
25 mg	$257	In Stock
50 mg	$513	In Stock
100 mg	$748	In Stock
1 mL x 10 mM (in DMSO)	$73	In Stock

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Batch Information

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Purity:97.85%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	TP-064 is a potent and selective PRMT4 inhibitor, featuring an IC50 < 10nM for methylation of H3 (1-25) and over 100-fold selectivity compared to other histone methyltransferases and non-epigenetic targets. It inhibits the methylation of MED12 in cells with an IC50 of 43 nM.
Targets&IC50	PRMT6:1300 μM, MED12:43 nM(IC50), PRMT4:<10 nM, BAF155:340 nM(IC50)
Synonyms	TP 064

Chemical Properties

Molecular Weight	458.6
Formula	C₂₈H₃₄N₄O₂
Cas No.	2080306-20-1
Smiles	CNCCN1CCC(CC1)c1cc(CN(C)C(=O)c2cccc(Oc3ccccc3)c2)ccn1
Relative Density.	1.134 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (272.57 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1805 mL	10.9027 mL	21.8055 mL	109.0275 mL
5 mM	0.4361 mL	2.1805 mL	4.3611 mL	21.8055 mL
10 mM	0.2181 mL	1.0903 mL	2.1805 mL	10.9027 mL
20 mM	0.1090 mL	0.5451 mL	1.0903 mL	5.4514 mL
50 mM	0.0436 mL	0.2181 mL	0.4361 mL	2.1805 mL
100 mM	0.0218 mL	0.1090 mL	0.2181 mL	1.0903 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc