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TP-064

🥰Excellent
Catalog No. T28996Cas No. 2080306-20-1
Alias TP 064

TP-064 is a potent and selective PRMT4 inhibitor, featuring an IC50 < 10nM for methylation of H3 (1-25) and over 100-fold selectivity compared to other histone methyltransferases and non-epigenetic targets. It inhibits the methylation of MED12 in cells with an IC50 of 43 nM.

TP-064

TP-064

🥰Excellent
Purity: 97.85%
Catalog No. T28996Alias TP 064Cas No. 2080306-20-1
TP-064 is a potent and selective PRMT4 inhibitor, featuring an IC50 < 10nM for methylation of H3 (1-25) and over 100-fold selectivity compared to other histone methyltransferases and non-epigenetic targets. It inhibits the methylation of MED12 in cells with an IC50 of 43 nM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$32In StockIn Stock
2 mg$45In StockIn Stock
5 mg$72In StockIn Stock
10 mg$122In StockIn Stock
25 mg$257In StockIn Stock
50 mg$513In StockIn Stock
100 mg$748-In Stock
1 mL x 10 mM (in DMSO)$73In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:97.85%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
TP-064 is a potent and selective PRMT4 inhibitor, featuring an IC50 < 10nM for methylation of H3 (1-25) and over 100-fold selectivity compared to other histone methyltransferases and non-epigenetic targets. It inhibits the methylation of MED12 in cells with an IC50 of 43 nM.
Targets&IC50
MED12:43 nM(IC50), BAF155:340 nM(IC50), PRMT6:1300 μM, PRMT4:<10 nM
SynonymsTP 064
Chemical Properties
Molecular Weight458.6
FormulaC28H34N4O2
Cas No.2080306-20-1
SmilesCNCCN1CCC(CC1)c1cc(CN(C)C(=O)c2cccc(Oc3ccccc3)c2)ccn1
Relative Density.1.134 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 125 mg/mL (272.57 mM), Sonication and heating to 60℃ are recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.72 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1805 mL10.9027 mL21.8055 mL109.0275 mL
5 mM0.4361 mL2.1805 mL4.3611 mL21.8055 mL
10 mM0.2181 mL1.0903 mL2.1805 mL10.9027 mL
20 mM0.1090 mL0.5451 mL1.0903 mL5.4514 mL
50 mM0.0436 mL0.2181 mL0.4361 mL2.1805 mL
100 mM0.0218 mL0.1090 mL0.2181 mL1.0903 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TP-064TP064PRMT4MED12InhibitorinhibitHistoneMethyltransferaseHistone MethyltransferasedimethylationCARM1BAF155anticancer
Related Tags: buy TP-064 | purchase TP-064 | TP-064 cost | order TP-064 | TP-064 chemical structure | TP-064 formula | TP-064 molecular weight
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