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Anti-Phospho-c-Jun (Ser63) Antibody (1C760)
Catalog No. TMAB-10505 Copy Product Info
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Anti-Phospho-c-Jun (Ser63) Antibody (1C760) is a Rabbit antibody targeting Phospho-c-Jun (Ser63). Anti-Phospho-c-Jun (Ser63) Antibody (1C760) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Anti-Phospho-c-Jun (Ser63) Antibody (1C760)
Copy Product Info🥰Excellent
Catalog No. TMAB-10505
Anti-Phospho-c-Jun (Ser63) Antibody (1C760) is a Rabbit antibody targeting Phospho-c-Jun (Ser63). Anti-Phospho-c-Jun (Ser63) Antibody (1C760) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Anti-Phospho-c-Jun
(Ser63) Antibody
(1C760)
(Ser63) Antibody
(1C760)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $261 | 7-10 days | 7-10 days | |
| 100 μL | $473 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-Phospho-c-Jun (Ser63) Antibody (1C760) is a Rabbit antibody targeting Phospho-c-Jun (Ser63). Anti-Phospho-c-Jun (Ser63) Antibody (1C760) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF. |
| Ig Type | IgG |
| Clone | 1C760 |
| Reactivity | Human,Mouse (predicted:Rat) |
| Verified Activity | 1. Sample: Lane 1: NIH/3T3 (Mouse) Cell Lysate at 30 μg Lane 2: Hela (Human) Cell Lysate at 30 μg Lane 3: SH-SY5Y (Human) Cell Lysate at 30 μg Lane 4: U251 (Human) Cell Lysate at 30 μg Primary: Anti-phospho-c-Jun (Ser63) (TMAB-10505) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 36/43 kD Observed band size: 43 kD 2. Paraformaldehyde-fixed, paraffin embedded (Human esophageal cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (phospho-c-Jun (Ser63)) Monoclonal Antibody, Unconjugated (TMAB-10505) at 1: 200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. 3. Paraformaldehyde-fixed, paraffin embedded (human laryngeal carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (phospho-c-Jun (Ser63)) Monoclonal Antibody, Unconjugated (TMAB-10505) at 1: 200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. 4. Paraformaldehyde-fixed, paraffin embedded (Human skin cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (phospho-c-Jun (Ser63)) Monoclonal Antibody, Unconjugated (TMAB-10505) at 1: 200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:50-500; IHC-Fr: 1:50-500; ICC/IF: 1:50-200; IF: 1:50-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | C-jun (Oncoprotein C-jun) is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements and appears to be a major downstream target of the SAPK/JNK signaling pathway. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress induced signaling pathways. The MAP kinase homologue, SAPK/JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human c-Jun around the phosphorylation site of Ser63 |
| Antigen Species | Human |
| Gene Name | JUN |
| Gene ID | |
| Protein Name | Transcription factor AP-1 |
| Uniprot ID | |
| Function | Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. |
| Molecular Weight | Theoretical: 36 kDa. Actual: 43/36 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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