Shopping Cart

Your shopping cart is currently empty

SynuClean-D

Name: SynuClean-D
Brand: TargetMol
SKU: T13048
Price: 139 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13048Cas No. 685121-45-3

Alias SC-D

SynuClean-D (SC-D) is an α-synuclein aggregation inhibitor that prevents fibril propagation, disrupts mature amyloid fibrils, and abolishes dopaminergic neuron degeneration in an animal model of Parkinson's disease.

SynuClean-D

🥰Excellent

Purity: 99.96%

Catalog No. T13048Alias SC-DCas No. 685121-45-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$139	In Stock	In Stock
5 mg	$297	In Stock	In Stock
10 mg	$488	In Stock	In Stock
25 mg	$863	In Stock	In Stock
50 mg	$1,230	In Stock	In Stock
100 mg	$1,650	-	In Stock
1 mL x 10 mM (in DMSO)	$336	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.96%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SynuClean-D (SC-D) is an α-synuclein aggregation inhibitor that prevents fibril propagation, disrupts mature amyloid fibrils, and abolishes dopaminergic neuron degeneration in an animal model of Parkinson's disease.
In vitro	SynuClean-D prevents fibril propagation in protein-misfolding cyclic amplification assays and decreases the number of α-synuclein inclusions in human neuroglioma cells. SynuClean-D significantly reduces the aggregation of wild-type α-synuclein and the familiar A30P and H50Q variants in a substoichiometric molar ratio. SynuClean-D can bind to cavities in mature α-synuclein fibrils[1].
In vivo	SynuClean-D-treated worms show decreased α-synuclein aggregation in muscle and a concomitant motility recovery. SynuClean-D is able to rescue dopaminergic neurons from α-synuclein-induced degeneration[1]. In two parkinson’s disease (PD) Caenorhabditis elegans models, SynuClean-D expresses α-synuclein either in muscle or in dopaminergic neurons and significantly reduces the toxicity exerted by α-synuclein[1].
Synonyms	SC-D

Chemical Properties

Molecular Weight	354.2
Formula	C₁₃H₅F₃N₄O₅
Cas No.	685121-45-3
Smiles	[O-][N+](=O)c1cccc(c1)-c1[nH]c(=O)c(C#N)c(c1[N+]([O-])=O)C(F)(F)F
Relative Density.	1.68 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (127.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.65 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8233 mL	14.1163 mL	28.2326 mL	141.1632 mL
5 mM	0.5647 mL	2.8233 mL	5.6465 mL	28.2326 mL
10 mM	0.2823 mL	1.4116 mL	2.8233 mL	14.1163 mL
20 mM	0.1412 mL	0.7058 mL	1.4116 mL	7.0582 mL
50 mM	0.0565 mL	0.2823 mL	0.5647 mL	2.8233 mL
100 mM	0.0282 mL	0.1412 mL	0.2823 mL	1.4116 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc