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B7-H4 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Catalog No. TMPJ-00176
Synonyms: B7H4T-cell costimulatory molecule B7x, FLJ22418, B7XPRO1291, B7x, V-set domai, B7-H4, B7S1, B7h.5, Immune costimulatory protein B7-H4, Vtcn1, B7S1VCTN1, V-set domain containing T cell activation inhibitor 1, T cell costimulatory molecule B7x, Protein B7S1

B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H4 consists of a 235 amino acid (aa) extracellular domain (ECD) with two Ig-like V-type domains, a 21 aa transmembrane segment, and a 2 aa cytoplasmic tail. It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
B7-H4 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Pack Size Availability Price/USD Quantity
20 μg 5 days $ 355.00
100 μg 5 days $ 963.00
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Biological Description
Technical Params
Product Properties
Description B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H4 consists of a 235 amino acid (aa) extracellular domain (ECD) with two Ig-like V-type domains, a 21 aa transmembrane segment, and a 2 aa cytoplasmic tail. It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.
Species Human
Expression System Human Cells
Tag C-Fc-Avi
Accession Number Q7Z7D3
Synonyms B7H4T-cell costimulatory molecule B7x, FLJ22418, B7XPRO1291, B7x, V-set domai, B7-H4, B7S1, B7h.5, Immune costimulatory protein B7-H4, Vtcn1, B7S1VCTN1, V-set domain containing T cell activation inhibitor 1, T cell costimulatory molecule B7x, Protein B7S1
Amino Acid Phe29-Ala258
Construction Biotinylated Recombinant Human B7 Homolog 4 is produced by our Mammalian expression system and the target gene encoding Phe29-Ala258 is expressed with a human IgG1 Fc, Avi tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 70-95 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H4 consists of a 235 amino acid (aa) extracellular domain (ECD) with two Ig-like V-type domains, a 21 aa transmembrane segment, and a 2 aa cytoplasmic tail. It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.

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Keywords

B7-H4 Protein, Human, Recombinant (hFc & Avi), Biotinylated B7H4T-cell costimulatory molecule B7x FLJ22418 B7XPRO1291 B7x V-set domai B7-H4 B7XPRO 1291 B7S1 FLJ-22418 B7h.5 Immune costimulatory protein B7-H4 Vtcn1 B7S1VCTN1 V-set domain containing T cell activation inhibitor 1 T cell costimulatory molecule B7x Protein B7S1 B7XPRO-1291 FLJ 22418 recombinant recombinant-proteins proteins protein

 

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