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SF 11

Name: SF 11
Brand: TargetMol
SKU: T23349
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23349Cas No. 443292-81-7

SF 11 is a potent, brain-penetrant neuropeptide Y Y2 receptor antagonist with an IC50 of 199 nM, exhibiting antidepressant-like activity.

SF 11

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Purity: 99.51%

Catalog No. T23349Cas No. 443292-81-7

SF 11 is a potent, brain-penetrant neuropeptide Y Y2 receptor antagonist with an IC50 of 199 nM, exhibiting antidepressant-like activity.

Pack Size	Price	Availability
2 mg	$31	In Stock
5 mg	$51	In Stock
10 mg	$83	In Stock
25 mg	$167	In Stock
50 mg	$293	In Stock
100 mg	$453	In Stock
200 mg	$609	In Stock

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Batch Information

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Purity:99.51%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	SF 11 is a potent, brain-penetrant neuropeptide Y Y2 receptor antagonist with an IC50 of 199 nM, exhibiting antidepressant-like activity.
Targets&IC50	NPYY2 receptor:199 nM (IC50)

Chemical Properties

Molecular Weight	446.6
Formula	C₂₇H₃₀N₂O₂S
Cas No.	443292-81-7
Smiles	C(O)(C1CCN(C(NC2=CC=C(OCC)C=C2)=S)CC1)(C3=CC=CC=C3)C4=CC=CC=C4
Relative Density.	1.31g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 22.33 mg/mL, Sonication is recommended.

DMSO: 40 mg/mL (89.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2391 mL	11.1957 mL	22.3914 mL	111.9570 mL
5 mM	0.4478 mL	2.2391 mL	4.4783 mL	22.3914 mL
10 mM	0.2239 mL	1.1196 mL	2.2391 mL	11.1957 mL
20 mM	0.1120 mL	0.5598 mL	1.1196 mL	5.5979 mL
50 mM	0.0448 mL	0.2239 mL	0.4478 mL	2.2391 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc