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Ogerin

Name: Ogerin
Brand: TargetMol
SKU: T16378
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16378Cas No. 1309198-71-7

Ogerin is a selective GPR68 positive allosteric modulator (pEC50: 6.83) that blocks recall in fear conditioning in mice. It exhibits inverse agonist and antagonist activity (Ki, 220 nM) at the A2A receptor and weak antagonist activity (Ki, 736 nM) at the 5-HT2B receptor.

Ogerin

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Purity: 99.75%

Catalog No. T16378Cas No. 1309198-71-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$65	In Stock	In Stock
10 mg	$111	In Stock	In Stock
25 mg	$227	In Stock	In Stock
50 mg	$381	In Stock	In Stock
100 mg	$567	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$74	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.75%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Ogerin AI Summary

Ogerin exhibits a wide range of bioactivities across various cell types and receptor interactions. It has shown varying effects on cell viability, with a growth rate of 1.0 in HEK293T cells, U2OS cells, and some human fibroblast cells, while displaying a growth rate of 0.0 in other instances with HEK293T and human fibroblast cells in Incucyte assays. As a potent allosteric modulator of both mouse and human GPR68, it stimulates proton-mediated cAMP production in HEK293T cells with an activity index ranging from 4.97 to 5.31 and a pKb from 4.13 to 4.35. The compound also affects proton-mediated calcium mobilization in HEK293T cells, with an EC50 of around 148.0 nM in the FLIPR-TETRA assay. Moreover, Ogerin has broad bioactivity, showing inhibitory effects on numerous serotonin, dopamine, adrenergic, opioid, histamine, muscarinic, GABA, and sigma receptors, as well as on serotonin and norepinephrine transporters. Notably, it has an EC50 of 147.91 nM and a Ki ranging from 489.78 to 496.36 nM for the 5-HT2B receptor, indicating significant binding affinity and receptor interaction. Furthermore, Ogerin impacts the thermal stability of protein domains, leading to both positive and negative shifts in melting temperature (TM), suggesting it interacts with multiple sites within proteins, potentially influencing their stability and function..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ogerin is a selective GPR68 positive allosteric modulator (pEC50: 6.83) that blocks recall in fear conditioning in mice. It exhibits inverse agonist and antagonist activity (Ki, 220 nM) at the A2A receptor and weak antagonist activity (Ki, 736 nM) at the 5-HT2B receptor.
Targets&IC50	GPR68:(pEC50)6.83 , A2A receptor:(ki)220 nM, 5-HT2B receptor:(ki)736 nM

Chemical Properties

Molecular Weight	307.35
Formula	C₁₇H₁₇N₅O
Cas No.	1309198-71-7
Smiles	Nc1nc(NCc2ccccc2)nc(n1)-c1ccccc1CO
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (813.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (16.27 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2536 mL	16.2681 mL	32.5362 mL	162.6810 mL
5 mM	0.6507 mL	3.2536 mL	6.5072 mL	32.5362 mL
10 mM	0.3254 mL	1.6268 mL	3.2536 mL	16.2681 mL
20 mM	0.1627 mL	0.8134 mL	1.6268 mL	8.1340 mL
50 mM	0.0651 mL	0.3254 mL	0.6507 mL	3.2536 mL
100 mM	0.0325 mL	0.1627 mL	0.3254 mL	1.6268 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc